卵巢储备功能减退的针灸治疗靶标研究进展  

Research progress on therapeutic targets of acupuncture and moxibustion for diminished ovarian reserve

作　　者：鞠文涵 相珊 赵帅 于艺 李园[2] 连方[2] Ju Wenhan;Xiang Shan;Zhao Shuai;Yu Yi;Li Yuan;Lian Fang(First Clinical Medical College of Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Reproductive and Genetic Center of Afiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011,China)

机构地区：[1]山东中医药大学第一临床医学院,济南250014 [2]山东中医药大学附属医院生殖与遗传科,济南250011

出　　处：《中华生殖与避孕杂志》2024年第4期376-379,共4页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金(82174429,82104914);中国博士后基金面上项目(2021M702044);山东省自然科学基金(ZR2023MH112)。

摘　　要：卵巢储备功能减退(diminished ovarian reserve,DOR)是指在绝经前提前出现的卵泡数量减少和卵母细胞质量下降,其发病机制尚未完全明确,临床治疗亦缺乏高效的手段,俨然成为生殖医学界亟待解决的难题。针灸由于操作方便、疗效好、见效快等优点,在全世界逐渐被推广用于妇科疾病的治疗。随着组学技术的飞速发展,DOR发病相关的分子靶标(蛋白质、核酸、受体等)被逐渐识别。本综述拟从针灸治疗DOR靶标的角度进行总结,以期为针灸治疗DOR的临床效果提供可靠依据。Diminished ovarian reserve(DOR)refers to the decrease in the number of follicles and the quality of oocytes that appear prematurely before menopause.The pathogenesis of DOR is not yet fully understood,and clinical treatment lacks efficient methods,making it an urgent problem to be solved in the field of reproductive medicine.Acupuncture and moxibustion has been gradually popularized in the world for the treatment of gynecological diseases due to its advantages such as convenient operation,good curative effect and quick effect.With the rapid development of omics technology,molecular targets related to DOR pathogenesis(proteins,nucleic acids,receptors,etc.)are gradually recognized.In this review,we plan to make a summary from the perspective of the target of acupuncture and moxibustion treatment of DOR,in order to provide a reliable basis for the clinical treatment of DOR.

关 键 词：卵巢储备功能减退 针灸 分子靶标 

分 类 号：R246.3[医药卫生—针灸推拿学]