DNA甲基化在辅助生殖技术胚胎及胎儿发育中的研究进展  

Research progress of DNA methylation in embryo and fetal development of assisted reproductive technology

作　　者：孙阿姣 熊正方[2] Sun Ajiao;Xiong Zhengfang(Graduate School of Qinghai University,Xining 810016,China;Reproductive Center of Qinghai People's Hospital,Xining 810007,China)

机构地区：[1]青海大学研究生院,西宁810016 [2]青海省人民医院生殖中心,西宁810007

出　　处：《中华生殖与避孕杂志》2024年第4期419-423,共5页Chinese Journal of Reproduction and Contraception

基　　金：青海省卫健委医药卫生科技项目(2020-wjzdx-32);中国科学院“西部之光”人才培养计划项目;2020年青海高原名医人才项目。

摘　　要：辅助生殖技术(assisted reproductive technology,ART)被认为是帮助不孕女性妊娠的重要手段。随着技术进展,ART的安全性越来越被广泛关注,而借助ART受孕相比自然受孕的妊娠结局较差。ART的相关操作可能通过表观遗传机制进而影响后代发育和健康。DNA甲基化则是研究最多的表观遗传调控机制。本文将对DNA甲基化在ART胚胎及胎儿发育中的研究进展进行简要综述,旨在为临床治疗提供新的思路。Assisted reproductive technology(ART)is considered to be an important means to help infertile women get pregnant.With the development of technology,the safety of ART has been paid more and more attention.However,the neonatal pregnancy outcome of ART is worse than that of natural conception.The operation of ART may affect the development and health of offspring through epigenetic mechanisms.DNA methylation is the most studied epigenetic regulatory mechanism.This article briefly reviewed the research progress of DNA methylation in ART embryo and fetal development,aiming to provide a new idea for clinical treatment.

关 键 词：DNA甲基化 胚胎发育 生殖技术 辅助 控制性卵巢刺激 

分 类 号：R714.8[医药卫生—妇产科学]