乙胺双碲醚的合成及GPx酶学性质研究  

Synthesis of Ethylamine Ditellurium Ether and Studies on Enzymatic Properties of GPx

作　　者：王慧玲 许洪峰 李佳锡 WANG Huiling;XU Hongfeng;LI Jiaxi(School of Materials Science and Engineering,Shenyang University of Chemical Technology,Shenyang Liaoning 110142,)

机构地区：[1]沈阳化工大学材料科学与工程学院,辽宁沈阳110142

出　　处：《当代化工》2024年第4期873-876,896,共5页Contemporary Chemical Industry

基　　金：辽宁省教育厅基本科研青年项目(项目编号:LJKQZ20222453)。

摘　　要：作为人体中一种非常重要的抗氧化酶,谷胱甘肽过氧化物酶(GPx)在清除人体生理反应产生的多余过氧化物中起到了非常重要的作用。由于人工智能GPx酶的催化活性较低,设计并合成出了同时含有GPx活性中心碲和两个伯氨基的乙胺双碲醚分子,当pH=7时活性为1.6±0.02μmol·min^(-1)·μmol^(-1),相较于经典小分子GPx人工硒酶提高了3个数量级。As a very important antioxidant enzyme in the human body,glutathione peroxidase(GPx)plays a very important role in the removal of excess peroxide produced by physiological reactions.Due to the low catalytic activity of artificial intelligence GPx enzyme,this paper designed and synthesized ethylamine ditellurium ether molecules containing GPx active center tellurium and two primary amino groups.When pH=7,the activity was 1.6±0.02μmol·min^(-1)·μmol^(-1),which was 3 orders of magnitude higher than that of classical small molecule GPx artificial enzyme.

关 键 词：谷胱甘肽过氧化物酶 双碲醚 催化活性 乒乓机制 

分 类 号：Q554[生物学—生物化学]