蛋白质过硫化修饰研究进展  

Research progress in protein persulfidation

作　　者：张博[1,2] 潘佳园 柳志强 郑裕国[1,2] ZHANG Bo;PAN Jiayuan;LIU Zhiqiang;ZHENG Yuguo(The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals,Zhejiang University of Technology,Hangzhou 310014,Zhejiang,China;Key Laboratory of Bioorganic Synthesis of Zhejiang Province,College of Biotechnology and Bioengineering,Zhejiang University of Technology,Hangzhou 310014,Zhejiang,China)

机构地区：[1]浙江工业大学手性生物制造国家地方联合工程研究中心,浙江杭州310014 [2]浙江工业大学生物工程学院、浙江省生物有机合成技术研究重点实验室,浙江杭州310014

出　　处：《微生物学报》2024年第5期1348-1363,共16页Acta Microbiologica Sinica

基　　金：国家重点研发计划(2018YFA0901400);国家自然科学基金(32070099,31971342)。

摘　　要：过硫化修饰在保护蛋白质的正常功能和信号传递过程中起着重要作用,对维持细胞的正常生理代谢平衡、保护细胞抵抗氧化应激及硫稳态调控等方面具有重要影响。本文综述了硫化氢、活性硫及半胱氨酸代谢的内在关联以及硫稳态调控,阐述了蛋白质过硫化修饰的机制及在微生物硫稳态调节中的作用,对未来的研究方向和趋势提供了新的思路。Persulfidation plays a role in protein functioning and signaling,maintaining the physiological and metabolic balance of cells,protecting cells from oxidative stress,and regulating sulfur homeostasis.This article summarized the internal relationship of hydrogen sulfide,reactive sulfur species,and cysteine metabolism,expounded the mechanism of sulfur homeostasis regulation,and introduced the role of persulfidation in microbial sulfur homeostasis,providing new thoughts for the future research.

关 键 词：过硫化修饰 硫化氢 活性硫 蛋白质 

分 类 号：Q933[生物学—微生物学]