瑞舒伐他汀对房颤消融术后患者心房纤维化的影响  

The effect of rosuvastatin on atrial fibrosis in patients after atrial fibrillation catheter ablation

作　　者：张素平 王学杰 张江 Zhang suping;Wang xuejie;Zhang jiang(Department of Cardiovascular Medicine,Hebi People's Hospital,Hebi,Henan,458030,China)

机构地区：[1]河南鹤壁市人民医院,458030

出　　处：《临床心电学杂志》2024年第2期98-101,共4页Journal of Clinical Electrocardiology

摘　　要：目的探究中剂量瑞舒伐他汀对行导管射频消融术的心房颤动患者,反映心房纤维化指标,血清趋化素(Chemerin)和半乳糖凝集素-3(Gal-3)水平的影响。方法选取我院2020年1月至2021年6月期间105例三维电解剖标测系统指导的首次行导管射频消融术的心房颤动术后患者作为研究对象,根据药物剂量不同分为常规组和研究组。常规组52例给予10mg/d治疗,研究组53例给予20mg/d治疗,6个月后,比较两组患者心室重构指标、血清炎症因子水平、心房纤维化程度。结果两组患者治疗6个月后左心室舒张期末容积(EDV)、左房射血分数(LVEF)水平较治疗前均升高,且研究组高于常规组;左房内径(LAD)水平较治疗前均降低,且研究组低于常规组(P<0.05)。两组患者治疗6个月后超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平较治疗前均降低,且研究组低于常规组(P<0.05)。两组患者治疗6个月后chemerin、Gal-3水平较治疗前均降低,且研究组低于常规组(P<0.05)。结论中剂量瑞舒伐他汀可调节行导管射频消融术的心房颤动患者血清炎症因子水平,改善心房纤维化程度,调控心室重构指标。Objective To investigate the effects of medium dose rosuvastatin on atrial fibrillation patients undergoing catheter radiofrequency ablation,reflecting indicators of atrial fibrosis and serum levels of chemokine and galactin-3.Methods One hundred and five patients with atrial fibrillation who underwent the first catheter radiofrequency ablation guided by the three-dimensional electrolytic mapping system in our hospital from January 2020 to June 2021 were selected as the study subjects.They were divided into a conventional group and a study group based on different drug doses.52 cases in the conventional group were treated with 10mg/d,while 53 cases in the study group were treated with 20 mg/d.After 6 months,the ventricular remodeling indicators,serum inflammatory factor levels,and degree of atrial fibrosis were compared between the two groups of patients.Results After 6 months of treatment,the levels of left ventricular end diastolic volume(EDV)and left atrial ejection fraction(LVEF)in both groups of patients increased compared to before treatment,and the study group was higher than the control group;The left atrial diameter(LAD)level decreased compared to before treatment,and the study group was lower than the control group(P<0.05).After 6 months of treatment,two groups of patients showed high sensitivity C-reactive protein(hs CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α) The level decreased compared to before treatment,and the study group was lower than the control group(P<0.05).After 6 months of treatment,the levels of chemerin and Gal-3 in both groups of patients decreased compared to before treatment,and the study group was lower than the control group(P<0.05).Conclusions Medium dose rosuvastatin can regulate serum inflammatory cytokine levels in patients with atrial fibrillation undergoing catheter radiofrequency ablation,improve the degree of atrial fibrosis,and regulate ventricular remodeling indicators.

关 键 词：瑞舒伐他汀 心房颤动 趋化素 半乳糖凝集素-3 

分 类 号：R541.7[医药卫生—心血管疾病] R540.41[医药卫生—内科学]