联合检测AMI患者心肌损伤标记物与NTproBNP的价值  

The expression of markers of myocardial injury and NT-proBNP in patients with acute myocardial infarction and the clinical significance of combined detection

作　　者：胡晶晶 梅玲凤 李舟 Hu jingjing;Mei lingfeng;Li zhou(Department of Emergency,The Third People's Hospital of Jiujiang City,Jiujiang,332000,China)

机构地区：[1]九江市第三人民医院,332000

出　　处：《临床心电学杂志》2024年第2期102-105,共4页Journal of Clinical Electrocardiology

摘　　要：目的探讨急性心肌梗死(AMI)患者血清cTnI、CK-MB、NT-proBNP的表达水平及3项联合检测的诊断价值。方法选择我院2021年10月至2023年10月间收治的AMI患者120例为AMI组,另选取同期住院治疗的冠心病不稳定型心绞痛患者60例为心绞痛组,同期健康体检志愿者60例为对照组。比较各组患者血清cTnI、CK-MB、NT-proBNP水平,AMI组患者不同时间段血清cTnI、CK-MB、NT-proBNP水平,分析cTnI、CK-MB、NT-proBNP联合检测的诊断价值。结果AMI组血清cTnI、CK-MB、NT-proBNP显著高于心绞痛组及对照组(P<0.001);心绞痛组与对照组血清cTnI、CK-MB及NT-proBNP比较差异均无统计学意义(P>0.05);cTnI、CK-MB、NT-proBNP在AMI患者入院2、6、12小时后持续升高(P<0.05),在入院12小时后到达峰值水平,之后开始逐渐下降并于入院5天后恢复到正常水平;ROC曲线下,3项指标联合检测的AUC、敏感度、特异度、阳性及阴性预测值均高于cTnI、CK-MB、NT-proBNP单独检测结果(P<0.05)。结论cTnI、CK-MB、NT-proBNP在AMI患者血清中均具有高表达且随着病情进展呈现动态变化,cTnI、CK-MB、NT-proBNP联合检测对于AMI的早期诊断、治疗及改善预后具有重要价值。Objective To investigate the expression level of cTnI,CK-MB and NT-proBNP in serum of patients with acute myocardial infarction(AMI)and the diagnostic value of three combined tests.Methods One hundred and twenty AMI patients admitted to our hospital from October 2021 to October 2023 were selected as AMI group,60 patients with unstable angina pectoris of coronary heart disease were selected as angina group and 60 healthy volunteers as control group.The serum levels of cTnI,CK-MB,NT-proBNP in each group were compared,and the serum levels of cTnI,CK-MB,NT-proBNP in different time periods in AMI group were analyzed.Results The serum cTnI,CK-MB and NT-proBNP in AMI group were significantly higher than those in angina pectoris group and control group(P<0.001);the serum cTnI,CK-MB and NT-proBNP in angina pectoris group and control group had no significant difference(P>0.05);cTnI,CK-MB and NT-proBNP continued to increase after 2,6 and 12 hours of admission(P<0.05),reached the peak level after 12 hours of admission,and then began to decline gradually and began to increase after 12 hours of admission.It returned to normal level 5 days after admission.The AUC,sensitivity,specificity,positive and negative predictive values of the three indexes were higher than those of cTnI,CK-MB and NT-proBNP(P<0.05).Conclusions cTnI,CK-MB and NT-proBNP are highly expressed in the serum of patients with AMI and show dynamic changes with the progress of the disease.The combined detection of cTnI,CK-MB and NT-proBNP is of great value for the early diagnosis,treatment and improvement of prognosis of AMI.

关 键 词：急性心肌梗死 CTNI CK-MB NT-PROBNP 联合检测 诊断价值 

分 类 号：R541.7[医药卫生—心血管疾病] R540.41[医药卫生—内科学]