沉默信息调节因子1与急性肺损伤/急性呼吸窘迫综合征  

Sirtuin1 and acute lung injury/acute respiratory distress syndrome

作　　者：岳阳 许天祥 代琴 吕红旭 王晓霞 YUE Yang;XU Tianxiang;DAI Qin

机构地区：[1]内蒙古医科大学内蒙古临床医学院,内蒙古呼和浩特010110 [2]内蒙古自治区人民医院肿瘤中心腹部肿瘤外科 [3]内蒙古科技大学包头医学院 [4]内蒙古自治区人民医院重症医学科

出　　处：《中国工业医学杂志》2024年第2期177-182,共6页Chinese Journal of Industrial Medicine

基　　金：内蒙古自治区自然科学基金(2023MS08019,2018LH08002);内蒙古自治区健康科技计划项目(202201011);内蒙古自治区人民医院院内基金(2020YN06);内蒙古医科大学联合项目(YKD2022LH015)。

摘　　要：沉默信息调节因子1(Sirtuin1,silent information regulator 1,SIRT1)是与酿酒酵母沉默信息调节器2(Sir2)同源的去乙酰化酶家族。SIRT1通过介导多条细胞信号通路,在细胞生物学功能和疾病发生机制中发挥关键作用,调节各种疾病的病理进展。在急性肺损伤(acute lung injury, ALI)/急性呼吸窘迫综合征(acute respiratory distress syndrome, ARDS)的动物模型中,SIRT1表达异常,且表达水平与模型的疾病严重程度密切相关,可能成为早期诊治ALI/ARDS新的生物学指标。本文简要综述了SIRT1通过抗炎、抗氧化应激、调节细胞凋亡及自噬、改变血管内皮细胞通透性等途径发挥其减轻ALI/ARDS的作用,探讨SIRT1在ALI/ARDS防治中的潜在价值。Sirtuin1(silent information regulator 1,SIRT1)is a family of deacetylases homologous to silent information regulator 2(Sir2)in Saccharomyces cerevisiae.SIRT1 plays a crucial role in cellular biological function and disease pathogenesis by mediating multiple cellular signaling pathways,regulating pathological progression of various diseases.In animal models of acute lung injury(ALI)/acute respiratory distress syndrome(ARDS),SIRT1 show abnormal expression and the expression level is closely related to the severity of the disease in the model,therefore,it is expected to become a new emerging biological indicator for early diagnosis and treatment of ALI/ARDS.This article briefly reviews the role of SIRT1 in reducing ALI/ARDS through anti-inflammatory,antioxidant stress,regulating cell apoptosis and autophage,and altering endothelial cell permeability,and the potential value of SIRT1 in the prevention and treatment of ALI/ARDS is explored as well.

关 键 词：沉默信息调节因子1(SIRT1) 生物学功能 急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS) 

分 类 号：R563[医药卫生—呼吸系统]