2.6GHz射频暴露条件下离体神经元网络的剂量学研究  

Dosimetric study of isolated neuronal networks under 2.6 GHz radiofrequency exposure

作　　者：汪雨晴 赵雪龙 刘琦 董国福 隗雨 陈妮 刘小曼 王长振 周红梅 WANG Yuqing;ZHAO Xuelong;LIU Qi;DONG Guofu;WEI Yu;CHEN Ni;LIU Xiaoman;WANG Changzhen;ZHOU Hongmei(College of Basic Medical Sciences,Anhui Medical University,Hefei 230032,China;Institute of Radiation Medicine,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China;College of Life Sciences,Hebei University,Baoding,Hebei 071000,China)

机构地区：[1]安徽医科大学基础医学院,合肥230032 [2]军事科学院军事医学研究院辐射医学研究所,北京100850 [3]河北大学生命科学学院,河北保定071000

出　　处：《军事医学》2024年第2期95-100,共6页Military Medical Sciences

摘　　要：目的评估微电极阵列(MEA)上离体培养神经元网络在2.6 GHz射频暴露条件下的剂量分布特性。方法将MEA与实时射频暴露装置耦合,采用电磁仿真软件计算离体培养神经元网络吸收的射频辐射剂量,采用光纤温度探头进行实验验证和射频暴露期间的细胞温度监测,MEA记录神经元电活动。结果注入功率为1 W时,贴壁神经元网络的比吸收率(SAR)为(15.51±2.48)W/kg,SAR分布变异度为16%,4 W/kg射频暴露引起细胞温升约为0.15℃。结论暴露装置在2.6 GHz频段可提供较高的SAR效率和均匀性,适用于研究5G网络频段射频场对神经元网络电活动的实时影响。Objective To evaluate the characteristics of dose distribution of neuronal networks in vitro on microelectrode arrays(MEAs)under 2.6 GHz radiofrequency(RF)exposure.Methods The MEAs were coupled with a real-time RF exposure setup,and electromagnetic simulation software was used to calculate the RF dose absorbed in cultured neuronal networks.A fiber-optic temperature probe was used for experimental validation and monitoring of the cell temperature during RF exposure.The MEAs were used to record the electrical activity of neurons.Results For an input power of 1 W,a specific absorption rate(SAR)level of(15.51±2.48)W/kg was calculated,and the variability of the SAR distribution was 16%.In our experimental system,the temperature elevation of neurons was up to 0.15℃for an SAR of 4 W/kg RF exposure.Conclusion The exposure device can provide high SAR efficiency and uniformity in the 2.6 GHz band,which is suitable for studying the real-time effects of RF fields on the electrical activity of neuronal networks in the 5G network band.

关 键 词：微电极阵列 射频场 神经元网络 剂量学 5G网络 

分 类 号：R81[医药卫生—放射医学]