乙醛脱氢酶2在疼痛调节中的研究进展  

Research progress on aldehyde dehydrogenase 2 in pain regulation

作　　者：彭文一 金世云[1] 李锐[1] Peng Wenyi;Jin Shiyun;Li Rui(Department of Anesthesiology and Perioperative Medicine,the Second Affiliated Hospital of Anhui Medical University,Key Laboratory of Anesthesiology and Perioperative Medicine,Anhui Normal University(Anhui Medical University),Hefei 230601,China)

机构地区：[1]安徽医科大学第二附属医院麻醉与围术期医学科,麻醉与围术期医学安徽普通高校重点实验室(安徽医科大学),合肥230601

出　　处：《国际麻醉学与复苏杂志》2024年第4期444-448,共5页International Journal of Anesthesiology and Resuscitation

基　　金：安徽省自然科学基金优秀青年项目(2208085Y28);安徽医科大学第二附属医院国家自然科学基金孵育计划项目(2021GMFY02)。

摘　　要：疼痛是一种与实际或潜在的组织损伤相关的不愉快的感觉和情绪情感体验。活性醛作为氧化应激的触发剂和产物,是介导疼痛发生、发展的重要因素之一。研究发现,乙醇代谢限速酶——乙醛脱氢酶2(ALDH2)在体内活性醛的清理中发挥关键作用,可成为疼痛调节过程中有效的干预靶点。文章重点梳理了活性醛诱发疼痛产生的相关通路以及ALDH2在疼痛调控中的作用机制,以期为临床中疼痛的个体化治疗提供可能的途径。Pain is an unpleasant feeling and emotional experience related to actual or potential tissue damage.Active aldehyde,as a trigger and product of oxidative stress,is one of the important factors to mediate the occurrence and development of pain.Researches have found that aldehyde dehydrogenase 2(ALDH2),a rate-limiting enzyme of ethanol metabolism,plays a key role in clearing active aldehyde in body.It is a promising target for the treatment and regulation of pain.In this review,we focus on the diverse pathways in which the reactive aldehydes induce or exacerbate pain symptoms,and further discuss the underlying mechanisms by which ALDH2 regulates the occurrence of pain,in order to provide a possible pathway for individualized pain treatment in clinical practice.

关 键 词：疼痛 氧化应激 活性醛 乙醛脱氢酶2 

分 类 号：R54[医药卫生—心血管疾病]