Pharmacological Effects of Botanical Drugs on Myocardial Metabolism in Chronic Heart Failure  

作　　者：HU Yu-xuan QIU Sheng-lei SHANG Ju-ju WANG Zi LAI Xiao-lei 

机构地区：[1]Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China

出　　处：《Chinese Journal of Integrative Medicine》2024年第5期458-467,共10页中国结合医学杂志（英文版）

基　　金：Supported by the National Key Research&Development Program (No.2019YFC1708602)。

摘　　要：Although there have been significant advances in the treatment of heart failure in recent years,chronic heart failure remains a leading cause of cardiovascular disease-related death.Many studies have found that targeted cardiac metabolic remodeling has good potential for the treatment of heart failure.However,most of the drugs that increase cardiac energy are still in the theoretical or testing stage.Some research has found that botanical drugs not only increase myocardial energy metabolism through multiple targets but also have the potential to restore the balance of myocardial substrate metabolism.In this review,we summarized the mechanisms by which botanical drugs(the active ingredients/formulas/Chinese patent medicines)improve substrate utilization and promote myocardial energy metabolism by activating AMP-activated protein kinase(AMPK),peroxisome proliferator-activated receptors(PPARs)and other related targets.At the same time,some potential protective effects of botanical drugs on myocardium,such as alleviating oxidative stress and dysbiosis signaling,caused by metabolic disorders,were briefly discussed.

关 键 词：botanical drugs chronic heart failure myocardial metabolism pharmacological effects REVIEW 

分 类 号：R285[医药卫生—中药学]