高甘油三酯葡萄糖指数与急性心肌梗死患者严重冠状动脉病变及不良预后相关  

High Triglyceride- glucose Index is Associated with Severe Coronary Artery Disease and Poor Prognosis in Patients with Acute Myocardial Infarction

作　　者：董征[1] 杨青苗[1] 郭彩霞 DONG Zheng;YANG Qingmiao;GUO Caixia(Department of Cardiovascular Center,Beijing Tongren Hospital,Capital Medical University,Bejing 100176,China)

机构地区：[1]首都医科大学附属北京同仁医院心血管中心,北京100176

出　　处：《中国分子心脏病学杂志》2024年第1期5858-5863,共6页Molecular Cardiology of China

基　　金：首都医科大学附属北京同仁医院青年杰出人才基金(2021-YJJ-ZZL-001)。

摘　　要：目的 探讨血清甘油三酯葡萄糖(triglyceride-glucose, TyG)指数与急性心肌梗死(acute myocardial infarction, AMI)患者冠状动脉病变严重程度和院内主要不良心血管事件(major adverse cardiovascular events, MACEs)的相关性。方法 回顾性分析2022年1月至2022年12月于北京同仁医院确诊的AMI并行冠脉造影(coronary angiography,CAG)检查且临床资料完整的360例患者。根据CAG结果,计算Gensini评分,并将患者分为Gensini评分高分组(≥64分,185例)和Gensini评分低分组(<64分,175例)。同时记录患者院内MACEs。Logistic回归分析用于危险因素分析。结果 Gensini评分高分组TyG指数(9.18±0.06)高于Gensini评分低分组(8.84±0.05)(P<0.001)。与低TyG指数组(<8.98, 180例)相比,高TyG指数组(≥8.98, 180例)患者发生院内MACEs的比例高(17.2%vs 10.0%,P=0.046)。多因素logistic回归分析结果显示TyG指数是高Gensini评分(OR=1.59,95%CI:1.04~2.43,P=0.032)和发生院内MACEs的危险因素(OR=1.79,95%CI:1.01~3.18,P=0.045)。结论 TyG指数与AMI患者冠状动脉病变严重程度和发生院内MACEs相关,TyG指数可能预测AMI患者的临床结局。Objective To explore the relationship between triglyceride-glucose(TyG) index and severity of coronary artery disease and in-hospital major adverse cardiovascular events(MACEs) in patients with acute myocardial infarction(AMI). Methods A total of 360 AMI patients underwent Coronary Angiography(CAG) examination with complete clinical data from January 2022 to December 2022 in Beijing Tongren Hospital were selected for retrospectively analyzed. According to the results of CAG, Gensini score was calculated. Patients were divided to high Gensini score group(≥64 points, n=185) and low Gensini score group(<64 points, n=175). In-hospital MACEs were recorded. Logistic regression analysis was used for risk factors analysis. Results TyG index in the high Gensini score group was higher than that in the low Gensini score group(9.18±0.06 vs 8.84±0.05,P<0.001). Compared with the low TyG index group(<8.98, n=180), the incidence of in-hospital MACEs was significantly higher in the high TyG index group(≥8.89, n=180)(17.2% vs 10.0%,P=0.046). Multivariate Logistic regression analysis showed that TyG index was a risk factor for high Gensini score(OR =1.59,95%CI: 1.04-2.43,P=0.032)and in-hospital MACEs(OR=1.79,95%CI: 1.01-3.18,P=0.045). Conclusion TyG index was associated with the severity of coronary artery disease and in-hospital MACEs in AMI patients. TyG index may predict the clinical outcomes of AMI patients.

关 键 词：甘油三酯葡萄糖指数 急性心肌梗死 GENSINI评分 主要不良心血管事件 

分 类 号：R542.22[医药卫生—心血管疾病]