中国8个长寿地区65岁及以上老年人血尿素氮与肌酐比值和衰弱的关联  

Effects of blood urea nitrogen to creatinine ratio on frailty in the elderly aged 65 years and older in 8 longevity areas in China

作　　者：陈子婷 高健 钟文芳 黄清湄 陈沛良 宋玮琦 王晓萌 钟逸诗 施小明[2] 毛琛 Chen Ziting;Gao Jian;Zhong Wenfang;Huang Qingmei;Chen Peiliang;Song Weiqi;Wang Xiaomeng;Zhong Yishi;Shi Xiaoming;Mao Chen(Department of Epidemiology,School of Public Health,Southern Medical University,Guangzhou 510515,China;China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing 100021,China)

机构地区：[1]南方医科大学公共卫生学院流行病学系,广州510515 [2]中国疾病预防控制中心环境与人群健康重点实验室/环境与健康相关产品安全所,北京100021

出　　处：《中华流行病学杂志》2024年第5期666-672,共7页Chinese Journal of Epidemiology

基　　金：广东省高水平大学建设计划(G623330580,G621331128);广东省高等学校珠江学者岗位计划(2019)。

摘　　要：目的探讨中国8个长寿地区≥65岁老年人血尿素氮与肌酐比值和衰弱的关联。方法研究对象来自老年健康生物标志物队列,利用血尿素氮与肌酐的基线信息和随访获得的衰弱事件,将血尿素氮与肌酐比值按五分位数分组,采用Cox比例风险回归模型分析血尿素氮与肌酐比值和衰弱发生风险的关联。结果共纳入1562名研究对象,年龄(81.0±17.0)岁,其中男性814名(52.1%)。(3.73±1.43)年随访期间共发生衰弱事件258名。Cox比例风险回归模型分析结果显示,在调整相关的混杂因素后,与血尿素氮与肌酐比值Q1组相比,Q3、Q4和Q5组的衰弱发生风险分别降低了36%[风险比(HR)=0.64,95%CI:0.43~0.94]、44%(HR=0.56,95%CI:0.38~0.84)和40%(HR=0.60,95%CI:0.41~0.88)。血尿素氮与肌酐比值每增加一个标准差,衰弱发生风险降低20%(HR=0.80,95%CI:0.70~0.91)。血尿素氮与肌酐比值和衰弱发生风险呈近线性剂量-反应关系。结论衰弱发生风险随着血尿素氮与肌酐比值的增加而呈下降趋势,维持较高的血尿素氮与肌酐比值对于预防老年人衰弱具有重要意义。Objective To explore the relationship between blood urea nitrogen to creatinine ratio and frailty in the elderly aged≥65 years in 8 longevity areas in China.Methods Participants were recruited from the Healthy Aging and Biomarkers Cohort Study.Based on baseline information about blood urea nitrogen and risk for frailty obtained at follow-up of the participants,blood urea nitrogen to creatinine ratio was classified according to quintiles,Cox proportional hazard regression models were used to analyze the association between blood urea nitrogen to creatinine ratio and frailty.Results A total of 1562 participants aged(81.0±17.0)years were included,in whom 814(52.1%)were men,and 258 frailty events occurred during a mean follow-up of(3.73±1.43)years.Cox proportional hazards model showed that after adjusting for relevant confounders,compared with the participants in the lowest quintile group(Q1),the risk for frailty decreased by 36%,44%,and 40% in the participants in the third quintile group(Q3),the fourth quintile group(Q4)and the highest quintile group(Q5)respectively[hazard ratio(HR)=0.64,95%CI:0.43-0.94;HR=0.56,95%CI:0.38-0.84;HR=0.60,95%CI:0.41-0.88].The risk for frailty decreased by 20% for every unit standard deviation increase in blood urea nitrogen to creatinine ratio(HR=0.80,95%CI:0.70-0.91).Moreover,blood urea nitrogen to creatinine ratio and the risk for frailty showed a nearly linear dose-response relationship.Conclusions The increase in blood urea nitrogen to creatinine ratio was associated with higher risk for frailty.Maintaining high blood urea nitrogen to creatinine ratio is important for the prevention of frailty in the elderly.

关 键 词：老年人 血尿素氮与肌酐比值 衰弱 队列研究 

分 类 号：R161.7[医药卫生—公共卫生与预防医学]