甘肃省2019-2022年原发性免疫性血小板减少症的流行病学特征分析  

Epidemiology of immune thrombocytopenia in Gansu Province,2019-2022

作　　者：焦永卓[1] 张晓曙[1] 王磊[2] 安婧[1] 刘舒瑜[1] 王华庆[2] Jiao Yongzhuo;Zhang Xiaoshu;Wang Lei;An Jing;Liu Shuyu;Wang Huaqing(Immunization Program Institute of Gansu Provincial Center for Disease Control and Prevention,Lanzhou 730000,China;Department of National Immunization Program,Chinese Center for Disease Control and Prevention,Beijing 100050,China)

机构地区：[1]甘肃省疾病预防控制中心免疫规划所,兰州730000 [2]中国疾病预防控制中心免疫规划中心,北京100050

出　　处：《中华流行病学杂志》2024年第5期708-713,共6页Chinese Journal of Epidemiology

基　　金：甘肃省卫生健康行业科研计划(GSWSKY2021-018)。

摘　　要：目的描述甘肃省2019-2022年原发性免疫性血小板减少症(ITP)人群中发病水平及流行病学特征,为ITP的诊治、病因学研究及该病与疫苗接种的关联性分析判断提供证据支持。方法使用Spark软件从甘肃省电子病历数据库中提取2019-2022年首次确诊的ITP病例,描述2019-2022年ITP新发病例的发病率及其流行病学特征,采用Poisson分布计算发病率,并估计其95%CI,使用Poisson回归进行组间差异比较。结果2019-2022年甘肃省首次诊断为ITP共4159例,总发病率为4.11/10万(95%CI:3.98/10万~4.23/10万),男性为3.49/10万(95%CI:3.33/10万~3.65/10万),女性为4.74/10万(95%CI:4.56/10万~4.94/10万),差异有统计学意义(P<0.001);儿童及老年人发病率高,男性在<10岁儿童及≥80岁老年人群中的发病风险高于女性,女性在成年以后(20~69岁)高于男性;甘肃省ITP发病峰值出现在夏季(6、7、8月),谷值在2、10月,各年龄组人群发病水平在一年中呈周期性变化;地区分布为东部和西部发病风险高,中部发病风险低。结论2019-2022年甘肃省儿童及老年人ITP发病率高,且男性发病风险高于女性,在总人群中女性发病风险较高,亦存在季节性和区域性高发现象。Objective To describe the incidence and epidemiological characteristics of immune thrombocytopenia(ITP)in Gansu Province from 2019 to 2022,and provide evidence for the diagnosis and treatment of ITP,related etiological research,and the association between ITP and vaccination.Methods Descriptive epidemiological method was used to describe the characteristics of new confirmed ITP cases during 2019-2022 by using the data collected from the electronic medical record database of Gansu.Results A total of 4159 cases of ITP were newly diagnosed in Gansu from 2019 to 2022;with an overall incidence of 4.11/100000(95%CI:3.98/100000-4.23/100000),the incidence was 3.49/100000 in men(95%CI:3.33/100000-3.65/100000),and 4.74/100000 in women(95%CI:4.56/100000-4.94/100000),the difference was significant(P<0.001).The incidence in children and the elderly was high,and the risk for ITP was higher in boys aged<10 years and men aged≥80 years than in girls,and the risk was higher in adult women(20-69 years)than in adult men.The incidence peak of ITP occurred in summer(June,July and August),and the incidence trough was in February or October in Gansu,and the annual incidence level in each age group showed cyclical changes.The risk for ITP was high in eastern and western areas,and low in central area.Conclusions The incidence of ITP were high in children and the elderly in Gansu in 2019-2022,and men were at higher risk for ITP compared with women,and higher risk for ITP was observed in women in total population.There were also seasonal and regional specific high incidence.

关 键 词：原发性免疫性血小板减少症 发病率 流行病学特征 电子病历数据库 

分 类 号：R558.2[医药卫生—血液循环系统疾病] R181.3[医药卫生—内科学]