当归补血汤与阿托伐他汀通过活化IGF1/IGF1R通路降低动脉粥样硬化斑块易损性  

Danggui-Buxue-Tang and Atorvastatin Reduced Atherosclerotic Plaque Vulnerability Through Activating IGF1/IGF1R Pathway

作　　者：陶宛璐 刘金兰 王丹萍 黄稳莹 王景颖 周怡君 吴文桐 崔璨[6] 单鸣 刘金鑫 Tao Wanlu;Liu Jinlan;Wang Danping;Huang Wenying;Wang Jingying;Zhou Yijun;Wu Wentong;Cui Can;Shan Ming;Liu Jinxin(Geriatric Department,Affiliated Hospital of Shandong Second Medical University,Weifang 261031,China;Clinical Research Center,Affiliated Hospital of Shandong Second Medical University,Weifang 261041,China;General Practice Department,Affiliated Hospital of Shandong Second Medical University,Weifang 261031,China;Nephrology Department,Affiliated Hospital of Shandong Second Medical University,Weifang 261031,China;School of Clinical Medicine,Shandong Second Medical University,Weifang 261053,China;Department of Endocrinology and Metabolism,The Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China;Center for Clinical Research,Affiliated Hospital of Qingdao University,Qingdao 266000,China)

机构地区：[1]山东第二医科大学附属医院老年医学科,山东潍坊261031 [2]山东第二医科大学附属医院临床研究中心,山东潍坊261041 [3]山东第二医科大学附属医院全科医学科,山东潍坊261031 [4]山东第二医科大学附属医院肾内科,山东潍坊261031 [5]山东第二医科大学临床医学院,山东潍坊261053 [6]哈尔滨医科大学附属第二医院内分泌与代谢科,黑龙江哈尔滨150086 [7]青岛大学附属医院临床研究中心,山东青岛266000

出　　处：《南开大学学报（自然科学版）》2024年第2期39-45,共7页Acta Scientiarum Naturalium Universitatis Nankaiensis

基　　金：山东省自然科学基金面上项目(ZR2020KH028,ZR2020QH286);山东省中医药科技项目(Z-2022080);哈尔滨医科大学第二附属医院横向课题(070500020518);潍坊市科技发展计划项目(2022YX036)。

摘　　要：为了探索当归补血汤(DBT)的抗动脉粥样硬化作用机制并比较其与阿托伐他汀抗动脉硬化作用的异同,利用高脂高胆固醇饮食饲喂ApoE-/-雄鼠(16周)模仿动脉粥样硬化易损斑块模型,分别给与DBT和立普妥干预8周,检测动脉粥样硬化进展相关指标.结果表明,DBT与立普妥均能降低血脂,减少巨噬细胞表型,抑制炎症因子和MMPs表达并促进细胞增殖,从而逆转动脉粥样硬化进展,减轻斑块负荷、降低斑块易损性,两给药组组间比较无统计学差异.结论是DBT有不弱于他汀类药物的抗动脉粥样硬化作用,可能的机制是通过上调IGF1表达并活化IGF1/IGF1R通路实现.In order to explore the anti-atherosclerosis mechanism of Danggui-Buxue-Tang Decoction(DBT)and compare the similarities and differences with the anti-arteriosclerosis effects of atorvastatin,ApoE-/-males(16-week old)were imitated the atherosclerotic vulnerable plaque model and were received DBT and Lipitor intervention for 8 weeks to detect the relevant indicators of atherosclerosis progression.Results showed that both DBT and Lipitor reduced blood lipid,reduced macrophage phenotype,suppressed inflammation,reduced ECM degradation and promoted cell proliferation,thus reversing atherosclerosis progression,reducing plaque load and reducing plaque vulnerability.There was no statistical difference between the two treatment groups.In conclusion,DBT plays an anti-atherosclerotic effect as well as statins do.The possible mechanism is through upregulation of IGF1 expression and activation of the IGF1/IGF1R pathway.

关 键 词：动脉粥样硬化 斑块易损性 当归补血汤 阿托伐他汀 胰岛素样生长因子1 

分 类 号：R541.4[医药卫生—心血管疾病]