加味小青龙汤治疗儿童支气管哮喘的效果及对患儿气道重塑及血清OPN、LTB4、Eotaxin水平的影响  

Effects of modified Xiaoqinglong decoction on children with bronchial asthma and its impact on airway remodeling and serum levels of OPN,LTB4 and Eotaxin

作　　者：袁业红[1] 孙晓旭[1] 张勇[1] 闫永彬 Yuan Yehong;Sun Xiaoxu;Zhang Yong;Yan Yongbin(Department of Pediatrics,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,School of Pediatrics of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院儿科河南中医药大学儿科医学院,郑州450000

出　　处：《中国实用医刊》2024年第6期113-117,共5页Chinese Journal of Practical Medicine

基　　金：河南省中医药科学研究专项课题(2023ZY2049)。

摘　　要：目的研究加味小青龙汤治疗儿童支气管哮喘(寒哮证)的效果及对患儿气道重塑及血清骨桥蛋白(OPN)、白三烯B4(LTB4)、嗜酸性粒细胞趋化因子(Eotaxin)水平的影响。方法回顾性收集2021年6月至2022年8月河南中医药大学第一附属医院收治的儿童支气管哮喘(寒哮证)患儿68例,按照随机数字表法分为对照组与观察组,每组34例。对照组予以布地奈德福莫特罗治疗,观察组在对照组治疗基础上予以加味小青龙汤治疗,两组均治疗4周。比较两组治疗前后中医症候积分,气道重塑指标[气道腔面积(AI)、气道横截面积(AO),气道壁面积(WA)和气道壁厚度(T)],血清OPN、LTB4、Eotaxin水平及肺功能[两组用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、呼气流量峰值(PEF)]。结果治疗4周后,两组气喘、胸闷、咳嗽、喉间喘鸣评分低于治疗前(P<0.05),AI、AO、WA和T均小于治疗前(P均<0.05),血清OPN、LTB4、Eotaxin水平低于治疗前(P<0.05),且观察组上述指标均低于对照组(P均<0.05)。治疗4周后,两组FVC、FEV1、PEF水平均高于治疗前,且观察组高于对照组(P<0.05)。结论加味小青龙汤治疗寒哮证儿童支气管哮喘可改善患儿中医证候,提高肺功能,可能与其调节细胞因子、抑制气道病理性重塑有关。Objective To investigate the effects of modified Xiaoqinglong decoction on children with bronchial asthma(cold wheezing syndrome)and its impact on airway remodeling and serum levels of osteopontin(OPN),leukotriene B4(LTB4)and eosinophilic chemotactic factor(Eotaxin).Methods A total of 68 children with bronchial asthma(cold wheezing)admitted to the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from June 2021 to August 2022 were selected retrospectively,and they were divided into the control group and the observation group by random number table method,with 34 cases in each group.The control group was treated with budesonide and formoterol,and the observation group was treated with modified Xiaoqinglong decoction based on the treatment of the control group.Both groups were treated for 4 weeks.Traditional Chinese medicine syndrome scores,airway remodeling indexes,including area of airway(AI),total airway cross sectional area(AO),airway wall area(WA),and airway wall thickness(T),serum levels of OPN,LTB4,Eotaxin,lung function assessed by forced vital capacity(FVC),forced expiratory volume in one second(FEV1)and peak expiratory flow(PEF)were compared between the two groups before and after treatment.Results After 4 weeks of treatment,the scores of asthma,chest tightness,cough,and wheezing in the two groups were lower than those before treatment(P<0.05),the airway remodeling indexes(AI,AO,WA,and T)were lower than those before treatment(all P<0.05).the serum levels of OPN,LTB4,and Eotaxin were lower than those before treatment(P<0.05),and the above indicators in the observation group were lower than those in the conrtol group(all P<0.05).After 4 weeks of treatment,the levels of FVC,FEV1,and PEF in both groups were higher than those before treatment,and the indexes in the observation group were higher than those in the control group(P<0.05).Conclusions Modified Xiaoqinglong decoction can improve the traditional Chinese medicine syndrome and lung function of children with bronchial asthma,wh

关 键 词：儿童 支气管哮喘 气道重塑 寒哮证 加味小青龙汤 骨桥蛋白 白三烯B4 嗜酸性粒细胞趋化因子 

分 类 号：R272[医药卫生—中医儿科学]