小柴胡汤在恶性肿瘤全程管理中的应用研究进展  

Application of Xiao Chaihutang in Comprehensive Management of Malignant Tumors:A Review

作　　者：赵越 王文萍[2] 李晓斌[2] 王华伟[2] 曹莹 ZHAO Yue;WANG Wenping;LI Xiaobin;WANG Huawei;CAO Ying(Graduate School,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)

机构地区：[1]辽宁中医药大学研究生学院,沈阳110847 [2]辽宁中医药大学附属医院,沈阳110032

出　　处：《中国实验方剂学杂志》2024年第12期219-231,共13页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点研发计划项目(2018YFC1311600);辽宁省“兴辽英才计划”基金项目(XLYC1802008)。

摘　　要：恶性肿瘤已超过中风及冠心病跃升成为全球70岁前的主要死因,其发病率正逐年增长,严重影响我国人民生活水平及社会经济发展。外科手术、放射治疗、化学治疗、靶向治疗、免疫治疗是西医干预肿瘤的主要手段,对延长患者生存期具有重要意义,但存在不良反应多、易耐药等弊端。中医药在肿瘤治疗中的疗效确切、应用广泛,成为了近年的研究热点。小柴胡汤出自《伤寒杂病论》,由柴胡、黄芩、人参、半夏、炙甘草、生姜、大枣组成,具有和解少阳、调和寒热阴阳、疏肝解郁之功效。该方及以其为基础变化的方药被广泛应用于肿瘤的各个阶段。该研究对近10年来小柴胡汤在肿瘤领域的国内外研究进行总结,探究小柴胡汤在阻断癌前病变、控制恶性肿瘤发展、降低干预后不良反应发生、缓解常见并发症上的作用及机制,以期拓展临床用药思路。Malignant tumors have surpassed stroke and coronary heart disease to become the main cause of death before the age of 70 in the world.The incidence of malignant tumors is increasing year by year,which seriously affects the living standards and social and economic development of our people.Surgery,radiotherapy,chemotherapy,targeted therapy and immunotherapy are the main means of Western medicine to intervene in tumors,which are of great significance for prolonging the survival time of patients,but there are many disadvantages such as adverse reactions and drug resistance.Traditional Chinese medicine has become a research hotspot in recent years because of its definite curative effect and wide application in tumor treatment.Xiao Chaihutang is derived from'Treatise on Febrile and Miscellaneous Diseases'.It is composed of Radix Bupleuri,Radix Scutellariae,Radix Ginseng,Rhizoma Pinelliae,Radix Glycyrrhizae Preparata,Ginger and Jujube.It has the effects of reconciling Shaoyang,reconciling cold and heat yin and yang,soothing liver and relieving depression.This prescription and the prescriptions based on it are widely used in various stages of tumor.This study summarizes the domestic and foreign research of Xiao Chaihutang in the field of cancer in the past 10 years,and explores the role and mechanism of Xiao Chaihutang in blocking precancerous lesions,controlling the development of malignant tumors,reducing the occurrence of adverse reactions after intervention,and alleviating common complications,in order to expand the clinical medication ideas.

关 键 词：小柴胡汤 恶性肿瘤 癌症 全程管理 癌前病变 

分 类 号：R2-0[医药卫生—中医学] R22R242R2-031R259R730.5R273R246.5R979.1