从“毒损脑络”理论探讨牙龈卟啉单胞菌与阿尔茨海默病的相关性  

Study on the Relationship between Porphyromonas gingivalis and Alzheimer's Disease from the Theory of“Toxin Damaging Brain Collaterals”

作　　者：徐曼如 朱月 陈金鑫 李捷 范依然 秦静波 伍文彬[1] XU Manru;ZHU Yue;CHEN Jinxin;LI Jie;FAN Yiran;QIN Jingbo;WU Wenbin(Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072)

机构地区：[1]成都中医药大学附属医院,成都610072

出　　处：《中药药理与临床》2024年第2期125-128,共4页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金(编号:82174358);四川省中医药管理局(编号:2023MS481);岐黄学者(国中医药人教函2022-256)。

摘　　要：阿尔茨海默病(Alzheimer’s Disease,AD)是一种与年龄有关的神经变性疾病,是全球老龄化背景下亟待解决的共同问题,迄今为止其发病机制尚未完全明确。近来有研究表示,牙龈卟啉单胞菌(Porphyromonas Gingivalis,P.g)与AD发病有密切关系。本文从“毒损脑络”理论出发,结合最近的研究进展,讨论牙龈卟啉单胞菌和AD发生的相关性,为AD等神经退行性疾病的中医治疗提供新思路。Alzheimer's disease(AD)is an age-related neurodegenerative disease,which is a common problem to be solved urgently under the background of global aging.So far,its pathogenesis has not been completely clear.Recently,studies have shown that Porphyromonas gingivalis(P.g)is closely related to the pathogenesis of AD.This paper,based on the theory of“toxin damaging brain collaterals”and in combination with recent research progress,discussed the correlation between P.g and AD,aiming to provide a new idea for the treatment of AD and other neurodegenerative diseases.

关 键 词：阿尔茨海默病 牙龈卟啉单胞菌 毒损脑络 神经炎症 

分 类 号：R277.7[医药卫生—中医学]