经皮穴位电刺激对双侧脑深部电刺激术帕金森病患者术后疲劳综合征的影响  

Effect of transcutaneous electrical acupoint stimulation on postoperative fatigue syndrome in patients with Parkinson′s diseases undergoing bilateral deep brain electrical stimulation

作　　者：付同 韩明明 康芳 黄祥 王海涛[2] 阚步凡 李娟[1] Fu Tong;Han Mingming;Kang Fang;Huang Xiang;Wang Haitao;Kan Bufan;Li Juan(Department of Anesthesiology,The First Hospital Affiliated to the University of Science and Technology of China(Anhui Provincial Hospital),Hefei 230036,China;College of Integrated Chinese and Western Medicine,Anhui University of Chinese Medicine,Hefei 230031,China;Department of Life Science and Medicine,University of Science and Technology of China,Hefei 230022,China)

机构地区：[1]中国科学技术大学附属第一医院(安徽省立医院)麻醉科,合肥230036 [2]安徽中医药大学中西医结合学院,合肥230031 [3]中国科学技术大学生命科学与医学部,合肥230022

出　　处：《中华麻醉学杂志》2024年第4期396-400,共5页Chinese Journal of Anesthesiology

基　　金：统筹推进世界一流大学和一流学科建设专项资金(YD9110002015);科技创新2030——"脑科学与类脑研究"重大项目(2021ZD0203100)。

摘　　要：目的评价经皮穴位电刺激(TEAS)对双侧脑深部电刺激术帕金森病患者术后疲劳综合征的影响。方法择期行双侧脑深部电刺激术帕金森病患者60例,年龄60~80岁,ASA分级Ⅱ或Ⅲ级,BMI 18.5~29.9 kg/m^(2),采用随机数字表法分为经皮穴位电刺激组(TEAS组)和假刺激组(Sham组),每组30例。TEAS组于入室后对患者持续行TEAS,选取患者双侧足三里穴、三阴交穴,选择疏密波,设置刺激频率为2/10 Hz,电流强度为6~15 mA。当神经外科医生进行微电极记录时停止刺激,微电极记录结束后继续刺激至手术结束;Sham组仅在相同时点在穴位贴电极片,不进行刺激。于术前1 d(T_(0))、术后1、3和7 d(T_(1-3))时进行Christensen评分,评估术后疲劳综合征的发生情况,记录术后15项恢复质量量表评分、苏醒期躁动发生和术后48 h内镇痛补救情况。结果与Sham组相比,TEAS组T_(1-3)时Christensen评分降低,术后15项恢复质量量表评分升高,术后疲劳综合征、苏醒期躁动发生率和镇痛补救率降低(P<0.05)。结论TEAS可降低双侧脑深部电刺激术帕金森病患者术后疲劳综合征的发生。Objective To evaluate the effect of transcutaneous electrical acupoint stimulation(TEAS)on postoperative fatigue syndrome in patients with Parkinson′s diseases undergoing bilateral deep brain electrical stimulation.Methods Sixty patients with Parkinson′s disease,aged 60-80 yr,of American Society of Anesthesiologists Physical Status classificationⅡorⅢ,with body mass index of 18.5-29.9 kg/m^(2),undergoing elective bilateral deep brain electrical stimulation,were divided into transcutaneous electrical acupoint stimulation group(TEAS group)and sham stimulation group(Sham group),with 30 patients in each group,using the random number table method.The TEAS of bilateral Zusanli and Sanyin points was performed on admission to the operating room with alternative stimulation at a frequency of 2/10 Hz and an intensity of 6-15 mA.The stimulation was stopped when the neurosurgeon performed the microelectrode recording,and TEAS was continued until the end of operation after the microelectrode recording was finished.In Sham group,electrode pads were only placed at the acupoint with no stimulation.The Christensen score was assessed at 1 day preoperatively(T_(0))and 1,3 and 7 days postoperatively(T_(1-3))to evaluate the occurrence of postoperative fatigue syndrome.The 15-item Quality of Recovery scale score,emergence agitation and rescue analgesia within 48 h after surgery were recorded.Results Compared with Sham group,Christensen scores were significantly decreased at T_(1-3),15-item Quality of Recovery scale scores were increased,and the incidence of postoperative fatigue syndrome and emergence agitation and rate of rescue analgesia were decreased in TEAS group than in Sham group(P<0.05).Conclusions TEAS can reduce the development of postoperative fatigue syndrome in the patients with Parkinson′s diseases undergoing bilateral deep brain electrical stimulation.

关 键 词：电刺激疗法 针刺穴位 帕金森病 术后疲劳综合征 

分 类 号：R614[医药卫生—麻醉学]