Spock1参与Adipogenesis通路在肥大型与扩张型心肌病中的机制探讨  

The mechanism of Spock1 involved in Adipogenesis pathway in hypertrophic and dilated cardiomyopathy

作　　者：朱荣利 刘颖[2] 柳明 易玮珏 吴凤敏 侯秀阳 封瑞 ZHU Rong-li;LIU Ying;LIU Ming;YI Wei-jue;WU Feng-min;HOU Xiu-yang;FENG Rui(Department of Pharmaceutical Toxicology,School of Pharmacy,China Medical University,Shenyang 110122;Department of Medical Biotechnology,Institute of Basic Medical Science of Liaoning Province,Shenyang 11010l;Tianjin Customs Technical Center for Safety of Industrial Products,Tianjin 300308,China)

机构地区：[1]中国医科大学药学院药物毒理学教研室,辽宁沈阳110122 [2]辽宁省基础医学研究所医学生物技术教研室,辽宁沈阳110101 [3]天津海关工业产品安全技术中心,天津300308

出　　处：《解剖科学进展》2024年第2期113-116,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金(31400981);辽宁省教育厅科学研究经费项目(L202003);2020年大学生创新创业训练项目(x202010159044)。

摘　　要：目的探讨SPARC(骨素)、cwcv和Kazal样结构域蛋白多糖1(Spock1)在肥大型与扩张型心肌病发生中的作用与分子机制。方法基于CNKI数据库明确Spock1在机体各组织中的表达情况,并获得Spock1参与信号通路的关联基因,对此关联基因进行GO和KEGG富集分析,对比同类基因与心脏疾病的关系,从而分析获得Spock1参与肥大型与扩张型心肌病的具体关联信息。结果Spock1在心脏中较高表达,并且其可能通过Adipogenesis信号通路参与肥大型心肌病(HCM)和扩张型心肌病(DCM)的发生与发展。结论Spock1可能与肥大型和扩张型心肌病等相关心血管疾病的发生密切相关,并可能成为心脏疾病发生发展的生物标记物,甚至可成为治疗心脏疾病的新靶点基因。Objective To investigate the role and molecular mechanism of SPARC(osteocalcin),cwcv and Kazal-like domain protein polysaccharide 1(Spock1)in the occurrence of hypertrophic and dilated cardiomyopathy.Methods Based on CNKI database,the expression of Spock1 in various tissues of the body was clarified,and the associated genes of Spock1 participating in the signaling pathway were obtained,and the GO and KEGG enrichment analysis were performed on the associated genes to compare the relationship between similar genes and heart disease,so as to obtain specific association information of Spock1 in hypertrophic and dilated cardiomyopathy.Results Spock1 was highly expressed in the heart,and it may be involved in the occurrence and development of hypertrophic cardiomyopathy(HCM)and dilated cardiomyopathy(DCM)through adipogenesis signaling pathway.Conclusion Spock1 may be closely related to the occurrence of hypertrophic and dilated cardiomyopathy and other cardiovascular diseases,and may become a biomarker for the occurrence and development of heart disease,or even a new target gene for the treatment of heart disease.

关 键 词：Spock1 信号通路 心脏疾病 富集分析 

分 类 号：R542.2[医药卫生—心血管疾病]