线粒体质量控制在心肌保护中的研究进展  

The progress of mitochondrial quality control in myocardial protection

作　　者：张世武 王梦伊 李倩竹 舒凤 张伟华[1] ZHANG Shi-wu;WANG Meng-yi;LI Qian-zhu;SHU Feng;ZHANG Wei-hua(Department of Pathophysiology,Harbin Medical University,Harbin 150080,China)

机构地区：[1]哈尔滨医科大学病理生理学教研室,黑龙江哈尔滨150080

出　　处：《解剖科学进展》2024年第2期220-224,共5页Progress of Anatomical Sciences

基　　金：国家自然科学基金(81970317)。

摘　　要：线粒体是细胞代谢和能量产生必不可少的细胞器,在维持心脏稳态方面发挥着重要作用。心肌细胞线粒体功能障碍,会导致心力衰竭、心肌病和心脏缺血/再灌注损伤等心血管疾病。线粒体质量控制(MQC)是真核细胞维持线粒体数量和功能相对稳定的重要机制,其包括线粒体自噬、线粒体融合和分裂、线粒体相关降解以及线粒体蛋白质转位相关降解。因此,线粒体质量控制在生理或病理条件下维持心肌细胞线粒体稳态方面起着至关重要的作用。Mitochondria are essential organelles for cell metabolism and energy production,and play an important role in maintaining heart homeostasis.Cardiomyocytes mitochondrial dysfunction can lead to cardiovascular diseases such as heart failure,cardiomyopathy,and cardiac ischemia/reperfusion injury.Mitochondrial quality control(MQC)is an important mechanism for eukaryotic cells to maintain the relative stability of number and function of mitochondria,including mitophagy,mitochondrial fusion and division,mitochondria-associated degradation,and mitochondrial protein translocation-associated degradation.Therefore,mitochondrial quality control plays a vital role in maintaining cardiomyocytes mitochondrial homeostasis under physiological or pathological conditions.

关 键 词：心肌细胞线粒体 线粒体自噬 心血管疾病 心肌保护 细胞代谢 线粒体融合 心肌病 线粒体质量控制 

分 类 号：R542.2[医药卫生—心血管疾病]