脓毒症肠功能障碍的机制及中医药干预研究进展  

Research progress on the mechanism of intestinal dysfunction in sepsis and intervention of traditional Chinese medicine

作　　者：盛业东 李琦 陈家豪 张卓君 沈丽娟[2] 陆曙[3] Sheng Yedong;Li Qi;Chen Jiahao;Zhang Zhuojun;Shen Lijuan;Lu Shu(Nanjing University of Chinese Medicine,Nanjing 210023,Jiangsu,China;Department of Critical Care Medicine,Wuxi Hospital Afiliated to Nanjing University of Chinese Medicine,Wuxi 214071 Jiangsu,China;Cardiovascular Medicine Department,Wuxi Hospital Afiliated to Nanjing University of Chinese Medicine,Wuxi 214071 Jiangsu,China)

机构地区：[1]南京中医药大学,江苏南京210023 [2]南京中医药大学无锡附属医院重症医学科,江苏无锡214071 [3]南京中医药大学无锡附属医院心血管科,江苏无锡214071

出　　处：《中国中西医结合急救杂志》2024年第1期106-111,共6页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：国家自然科学基金(82274427,82374346);江苏省无锡市卫计委青年医学重点人才项目(QNRCO19)。

摘　　要：脓毒症发病率高,治疗难度大,病死率高,是临床治疗的难点。肠道一直被认为是多器官功能障碍综合征(MODS)的“马达”。肠功能障碍是脓毒症常见的并发症之一,因发生隐蔽常被忽视,且临床疗效欠佳而导致预后不良。因此,对脓毒症肠功能障碍的发病机制及治疗进行深入探索具有重要意义。中医药作为临床治疗脓毒症肠功能障碍的有效补充越来越受到临床医师的重视。现通过总结脓毒症肠功能障碍发病机制的研究进展,归纳中医药的临床应用,以期为脓毒症的临床救治提供更多思路和参考。Sepsis presents challenges in clinical treatment due to its high incidence,difficult treatment,and high fatality rate.The intestine has long been considered the"motor"of multiple organ dysfunction syndrome(MODS).Intestinal dysfunction is one of the common complications of sepsis,which is often neglected due to its hidden occurrence and poor clinical efficacy,leading to poor prognosis.Therefore,it is of great significance to explore the pathogenesis and treatment of intestinal dysfunction in sepsis.As an effective supplement for the clinical treatment of intestinal dysfunction in sepsis,Traditional Chinese medicine has been paid more and more attention by clinicians.This article summarizes the research progress on the pathogenesis of sepsis-induced intestinal dysfunction and the clinical application of traditional Chinese medicine(TCM),aiming to provide more ideas and references for the clinical treatment of sepsis.

关 键 词：脓毒症 肠功能障碍 发病机制 中医药 

分 类 号：R459.7[医药卫生—急诊医学]