加强慢性肾脏病患者的用药安全管理  

Strengthen medication safety management in patients with chronic kidney disease

作　　者：侯文婧 温爱萍[1] Hou Wenjing;Wen Aiping(Department of Pharmacy,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院药学部,北京100050

出　　处：《药物不良反应杂志》2024年第5期257-260,共4页Adverse Drug Reactions Journal

摘　　要：慢性肾脏病(CKD)已成为全球公共卫生问题,疾病管理的重点是减缓病情进展,药物治疗是CKD患者治疗的重要组成部分。但CKD患者肾功能下降,且通常存在病程较长、多病共存、多重用药等特点,药物不良事件发生风险更高。建议通过以下4个方面的措施促进CKD患者用药安全:(1)积极开展各项研究,补充和完善CKD患者用药相关循证证据;(2)根据肾小球滤过率调整CKD患者药物剂量后,加强用药后监测,对剂量进行动态管理;(3)实施CKD多学科综合管理;(4)积极运用信息化手段。Chronic kidney disease(CKD)has become a global public health problem.Slowing disease progression is vital in CKD management,and drug therapy is an important part of the treatment for CKD patients.However,the risk for adverse drug event is higher in patients with CKD due to impaired renal function,prolonged disease duration,presence of multimorbidity and polypharmacy.Therefore,it was recommended to promote medication safety in patients with CKD through the following 4 specific strategies:(1)carrying out more studies to improve evidence-based practice for medication in patients with CKD;(2)conducting dose adjustments according to glomerular filtration rate and continuous drug therapy monitoring to a dynamic management of the dose;(3)implementing multidisciplinary care;(4)utilizing appropriate information technology actively.

关 键 词：肾功能不全 循证医学 决策支持系统 管理 用药安全 

分 类 号：R692[医药卫生—泌尿科学] R95[医药卫生—外科学]