慢性肾脏病患者肠道微生态与免疫的关系研究进展  

Research progress on the relationship between intestinal microecology and immunity in patients with chronic kidney disease

作　　者：吴燕升 张先闻[1] 王琳[1] Yansheng Wu;Xianwen Zhang;Lin Wang(Department of Nephrology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院肾病科,200032

出　　处：《中华肾病研究电子杂志》2024年第2期101-105,共5页Chinese Journal of Kidney Disease Investigation（Electronic Edition）

基　　金：上海申康医院发展中心资助项目(SHDC2020CR2048B);国家自然科学基金资助项目(81273730,81904126)。

摘　　要：肠道微生物构成人体的肠道微生态系统,参与人体的营养、代谢、免疫等生理病理功能。研究发现,肠道微生态与慢性肾脏病关系密切。肠道微生态通过参与患者的先天性和适应性免疫应答,深刻影响慢性肾脏病进展及其相关并发症发生。而且,由肠道菌群参与构建的肠道黏膜免疫,直接影响着IgA的产生和分泌,从而影响IgA肾病的发生和进展。本文综述了慢性肾脏病患者肠道微生态与免疫的关系研究进展,以期为慢性肾脏病的诊治提供新的线索和思路。Intestinal microorganisms constitute the intestinal microecosystem of human body, and participate in physiopathological functions such as nutrition, metabolism, and immunity. Research findings have indicated that intestinal microecology is closely related to chronic kidney disease. By participating in the innate and adaptive immune responses of patients, intestinal microecology profoundly influences the progression of chronic kidney disease and its associated complications. Moreover, the intestinal mucosal immunity constructed by intestinal flora directly affects the production and secretion of IgA, thus affecting the occurrence and progression of IgA nephropathy. This article reviewed the research progress on the relationship between intestinal microecology and immunity in patients with chronic kidney disease, in order to provide new clues and ideas for the diagnosis and treatment of CKD.

关 键 词：慢性肾脏病 肠道微生态 免疫 

分 类 号：R692[医药卫生—泌尿科学]