铁棒锤炮制方法及“减毒存效”炮制原理研究进展  

Research progress on processing method of Aconitum pendulum Busch and the processing principle of“reducing toxicity and retaining effectiveness”

作　　者：曹瑞 牛江涛 金辉 陈红刚 李越峰 CAO Rui;NIU Jiangtao;JIN Hui;CHEN Honggang;LI Yuefeng(College of Pharmacy,Gansu University of Chinese Medicine,Lanzhou,Gansu,730101,China;Gansu Key Laboratory of Quality and Standards of Chinese Medicine,Lanzhou,Gausu,730000,China;College of Medicine,Qinghai University,Xining,Qinghai,810000,China)

机构地区：[1]甘肃中医药大学药学院,甘肃兰州730101 [2]甘肃省中药质量与标准研究重点实验室,甘肃兰州730000 [3]青海大学医学部,青海西宁810000

出　　处：《甘肃中医药大学学报》2024年第2期81-85,共5页Journal of Gansu University of Chinese Medicine

基　　金：甘肃省中药质量与标准研究重点实验室开放基金项目(zyzx-2020-23)。

摘　　要：通过查阅和整理近年来的相关文献,主要从铁棒锤的炮制方法、炮制对其化学成分及药理作用的影响及“减毒存效”的炮制原理等3个方面对铁棒锤的炮制研究进展进行概述。发现铁棒锤较常用、规范的炮制方法为水煮法、蒸制法及砂炒法,为规范铁棒锤的炮制工艺、阐明铁棒锤“减毒存效”的炮制原理、铁棒锤的深入研究开发及临床安全用药提供参考。By reviewing and sorting out the relevant literature in recent years,an overview of Aconitum pendulum Busch is provided from its processing methods,the influence of processing on its chemical composition and pharmacological action,and the processing principle of“reducing toxicity and retaining effectiveness”.It was found that the commonly used and standardized processing methods of Aconitum pendulum Busch are boiling,steaming,and sand frying.This provides reference for standardizing the processing technology of Aconitum pendulum Busch,clarifying the processing principle of“reducing toxicity and retaining effectiveness”of Aconitum pendulum Buschrod,a s well as its in-depth research and development,and clinical medication safety.

关 键 词：铁棒锤 炮制方法 化学成分 药理活性 减毒存效 综述 

分 类 号：R283.1[医药卫生—中药学]