Stereochemical editing:Catalytic racemization of secondary alcohols and amines  

作　　者：Jun Zhang Zhiyao Zheng Can Zhu 

机构地区：[1]Department of Chemistry,Fudan University,Shanghai 200438,China [2]Department of Organic Chemistry,Arrhenius Laboratory,Stockholm University,Stockholm 10691,Sweden

出　　处：《Chinese Chemical Letters》2024年第5期17-31,共15页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China (No. 22271054);the “1000-Youth Talents Plan”;Fudan University (start-up grant) for financial support.

摘　　要：Chiral alcohols and amines are important structural units widely existing in pharmaceuticals,agrochemicals,and food additives.Dynamic kinetic resolution(DKR)is an efficient strategy to deliver optically active alcohols and amines from their racemates.For the development of DKR method,racemization catalyst plays as a crucial element with the requirement of compatibility with the kinetic resolution(KR)system.In this paper,recent advance in the catalytic racemization of secondary alcohols and amines is summarized based on different types of racemizing intermediates,which are redox racemization via ketone/imine intermediates,racemization via radical intermediates,and racemization via carbocation intermediates.Enzymatic racemization of secondary alcohols and amines is also enclosed.

关 键 词：RACEMIZATION Secondary alcohols AMINES Kinetic resolution Dynamic kinetic resolution 

分 类 号：O621.251[理学—有机化学]