S-(1,3-Dioxoisoindolin-2-yl)O,O-diethyl phosphorothioate (SDDP): A practical electrophilic reagent for the phosphorothiolation of electron-rich compounds  

作　　者：Ze-Yuan Ma Mei Xiao Cheng-Kun Li Adedamola Shoberu Jian-Ping Zou 

机构地区：[1]Key Laboratory of Organic Synthesis of Jiangsu Province,College of Chemistry and Chemical Engineering,Soochow University,Suzhou 215123,China

出　　处：《Chinese Chemical Letters》2024年第5期151-154,共4页中国化学快报（英文版）

基　　金：generous financial support by National Natural Science Foundation of China(No.21472133);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);Key Laboratory of Organic Synthesis of Jiangsu Province(No.KJS1749).

摘　　要：An efficient synthesis of the electrophilic reagent,S-(1,3-dioxoisoindolin-2-yl)O,O-diethyl phosphorothioate(SDDP)is described.Moreover,the synthetic applications of SDDP wherein the transfer of the SP(O)(OEt)_(2) moiety occurs were investigated.In this manner,SDDP underwent facile SP(O)(OEt)_(2) transfer with electron-rich substrates such as ketones,indoles,and thiols to formα-phosphorothiolated ketones,3-phosphorothiolated indoles and S-phosphorothiolated thioethers,respectively.

关 键 词：Electrophilic reagent Phosphorothiolation Electrophilic substitution 

分 类 号：TQ265.1[化学工程—有机化工] TQ421