Convergent synthesis and immunological study of oligosaccharide derivatives related to galactomannan from Antrodia cinnamomea  

作　　者：Shuying Li Weiwei ZhuGe Xuan Sun Chongzhen Sun Zhaojun Liu Chenghe Xiong Min Xiao Guofeng Gu 

机构地区：[1]National Glycoengineering Research Center and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology,Shandong University,Qingdao 266237,China [2]NMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate-based Medicine,Shandong University,Qingdao 266237,China

出　　处：《Chinese Chemical Letters》2024年第5期155-160,共6页中国化学快报（英文版）

基　　金：supported by grants from the National Key Research and Development Program of China(No.2018YFA0902000);the National Natural Science Foundation of China(No.21877074).

摘　　要：The galactomannan from Antrodia cinnamomea(AC)is characterized as one of the important bioactive components that exhibits potential immunostimulatory propriety.The biological function of its corresponding oligosaccharide fragments has not been revealed yet.In this study,we reported the first chemical synthesis of the series of oligosaccharide fragments related to AC galactomannan via the convergent glycosylation strategy.The preliminary immunological evaluation of these synthesized AC oligosaccharides disclosed that the backbone tetrasaccharide 1d showed the best immunomodulatory ability on enhancing proliferation,phagocytosis and cytokines secretion of Raw264.7 macrophages in vitro,indicating its immense potential as an immunostimulant candidate.

关 键 词：Antrodia cinnamomea GALACTOMANNAN OLIGOSACCHARIDE Immunostimulatory propriety Chemical synthesis 

分 类 号：TQ460.1[化学工程—制药化工]