taBOX: A water-soluble tetraanionic rectangular molecular container for conjugated molecules and taste masking for berberine and palmatine  

作　　者：Qihan Lin Jiabin Xing Yue-Yang Liu Gang Wu Shi-Jia Liu Hui Wang Wei Zhou Zhan-Ting Li Dan-Wei Zhang 

机构地区：[1]Department of Chemistry,Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials,Fudan University,Shanghai 200438,China

出　　处：《Chinese Chemical Letters》2024年第5期175-178,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.22271059,21921003,21890730 and 21890732)for financial support.

摘　　要：A water-soluble macrocycle that bears four carboxylate anions has been designed and prepared,which forms a rectangular cavity that can efficiently encapsulate discrete electron-deficient aromatic compounds,including berberine and palmatine.This macrocycle is revealed to be highly biocompatible and able to inhibit the bitter taste of the two drugs.

关 键 词：MACROCYCLE Multianion Molecular container Molecular recognition Bitter taste masking 

分 类 号：TQ460.1[化学工程—制药化工] O641.3[理学—物理化学]