线粒体靶向抗氧化剂MitoQ研究进展  

Research Progress on Mitochondrial Targeted Antioxidant MitoQ

作　　者：谭宁 李巴仑 艾力·艾尔肯 赵献军 华进联[1] TAN Ning;LI Ba-Lun;Aili·AIERKEN;ZHAO Xian-Jun;HUA Jin-Lian(College of Veterinary Medicine/Shaanxi Centre of Stem Cells Engineering&Technology,Northwest A&F University,Yangling 712100,China;BaiOuPai(Tianjin)Biotechnology Co.,Ltd.,Tianjin 300350,China)

机构地区：[1]西北农林科技大学动物医学院/陕西省干细胞工程技术研究中心,杨凌712100 [2]百欧派(天津)生物技术有限公司,天津300350

出　　处：《农业生物技术学报》2024年第6期1432-1439,共8页Journal of Agricultural Biotechnology

基　　金：国家自然科学基金(32072806);陕西省重点科技创新团队项目(2019TD-036);百欧派(天津)生物技术有限公司资助。

摘　　要：米托蒽醌甲磺酸盐(mitoquinone mesylate,MitoQ)作为一种线粒体靶向抗氧化剂,已被证明能够减缓线粒体的氧化应激损伤、靶向线粒体以抵抗凋亡等,维持机体健康。现有研究已经证明MitoQ对于细胞损伤、器官损伤修复及各类疾病治疗具有重要的作用。本文综述了MitoQ的抗氧化、抵抗细胞炎症凋亡和其线粒体靶向性等生物学功能,并系统总结了MitoQ治疗神经退行性疾病、心血管损伤、代谢器官损伤和糖尿病的研究进展。本文为MitoQ在细胞生物学和临床疾病治疗中的应用提供参考。As a mitochondria-targeted antioxidant,mitoquinone mesylate(MitoQ)has been proved to relieve oxidative stress damage of mitochondria,target mitochondria to resist apoptosis,and maintain body health.Existing research has proven that MitoQ plays an important role in cell damage,organ damage repair and the treatment of various diseases.This paper reviews the biological functions of MitoQ such as antioxidant,resistance to cell inflammation and apoptosis,and its mitochondrial targeting,and systematically summarizes the research progress of MitoQ in the treatment of neurodegenerative diseases,cardiovascular injury,metabolic organ injury,and diabetes.This review provides reference for the use of MitoQ in cell biology and clinical disease treatment.

关 键 词：米托蒽醌甲磺酸盐(MitoQ) 线粒体 抗氧化 治疗 

分 类 号：R310.11[医药卫生—基础医学]