调周益经汤联合雌孕激素序贯疗法对卵巢储备功能下降性不孕的临床研究  

Clinical study of Tiaozhouyijing Decoction combined with estrogen and progesterone sequential therapy in the treatment of infertility with decreased ovarian reserve

作　　者：喻小燕 杨赟 宋淑慧 章雅琼 YU Xiaoyan;YANG Yun;SONG Shuhui;ZHANG Yaqiong(Department of Traditional Chinese Medicine,Jiangxi Medical College,Jiangxi Province,Shangrao334000,China;Department of Gynecology,Shangrao Maternal and Child Health Hospital,Jiangxi Province,Shangrao334000,China)

机构地区：[1]江西医学高等专科学校中医科,江西上饶334000 [2]江西省上饶市妇幼保健院妇科,江西上饶334000

出　　处：《中国当代医药》2024年第16期103-107,共5页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2022B543)。

摘　　要：目的观察调周益经汤联合雌孕激素序贯疗法对卵巢储备功能下降(DOR)性不孕的临床效果。方法选取2022年6月至2023年6月上饶市妇幼保健院诊断为DOR性不孕且符合肝郁肾虚型的60例患者作为研究对象,采用随机数字表法将其分为试验组(30例)和对照组(30例)。试验组采用调周益经汤联合雌孕激素序贯疗法,对照组采用雌孕激素序贯疗法。比较两组患者的中医证候疗效、妊娠率、相关激素水平[包括促卵泡生成素(FSH)、促黄体生成素(LH)、雌二醇(E_(2))、抗米勒管激素(AMH)]、卵巢的窦卵泡数。结果试验组的中医证候疗效、妊娠率、均高于对照组,窦卵泡数多于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的FSH、LH水平均低于本组治疗前,E_(2)、AMH水平均高于本组治疗前,差异有统计学意义(P<0.05);治疗后,试验组的FSH、LH水平均低于对照组,AMH水平高于对照组,差异有统计学意义(P<0.05);两组患者治疗后的E_(2)水平比较,差异无统计学意义(P>0.05)。结论调周益经汤联合雌孕激素序贯疗法可明显改善患者的相关临床症状,增加窦卵泡数,提高妊娠率,调节激素水平,该方案对DOR性不孕患者的治疗效果显著。Objective To observe the clinical effect of Tiaozhouyijing Decoction combined with estrogen and progesterone sequential therapy in the treatment of infertility with decreased ovarian reserve(DOR).Methods From June 2022 to June 2023,a total of 60 patients diagnosed with DOR infertility in Shangrao Maternal and Child Health Hospital and in line with liver stagnation and kidney deficiency were selected as the research objects,and they were divided into experimental group(30 cases)and control group(30 cases)by random number table method.The experimental group was treated with Tiaozhouyijing Decoction combined with estrogen and progesterone sequential therapy,and the control group was treated with estrogen and progesterone sequential therapy.The traditional Chinese medicine syndrome efficacy,pregnancy rate,related hormone levels(including follicle stimulating hormone[FSH],luteinizing hormone[LH],estradiol[E_(2)],anti-Müllerian hormone[AMH]),and the number of antral follicles were compared between the two groups.Results The efficacy of traditional Chinese medicine syndrome and pregnancy rate in the experimental group were higher than those in the control group,and the number of antral follicles in the experimental group were more than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of FSH and LH in the two groups were lower than those before treatment,and the levels of E_(2) and AMH were higher than those before treatment,and the differences were statistically significant(P<0.05).After treatment,the levels of FSH and LH in the experimental group were lower than those in the control group,and the level of AMH was higher than that in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in E_(2) levels between the two groups after treatment(P>0.05).Conclusion Tiaozhouyijing Decoction combined with estrogen and progesterone sequential therapy can significantly improve the related clinical symptoms o

关 键 词：卵巢储备功能下降 不孕 肝郁肾虚 调周益经汤 雌孕激素序贯疗法 临床疗效 

分 类 号：R711.6[医药卫生—妇产科学]