右心室不同部位起搏患者术后左心室收缩功能的变化  

Changes in left ventricular systolic function in patients after pacing in different sites of right ventricle

作　　者：谭顺林 张胜[1] 陈丽 黄蕾 TAN Shun-lin;ZHANG Sheng;CHEN Li;HUANG Lei(Department of Cardiology,Ziyang First People's Hospital,Ziyang,Sichuan,641300,China)

机构地区：[1]资阳市第一人民医院心血管内科,四川资阳641300

出　　处：《心血管康复医学杂志》2024年第3期298-302,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨右心室不同部位起搏患者术后左心室收缩功能的变化。方法:收集本院2018年2月至2020年5月收治的95例需进行右心室起搏患者的临床资料,根据起搏部位的不同将其分为右室心尖部起搏(RVAP)组(n=47)以及右室间隔部起搏(RVSP)组(n=48)。比较两组起搏阈值、感知阈值、电极阻抗、左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)、每搏量(SV)、左室射血分数(LVEF)。根据术后1年是否发生心功能不全,患者被分为心功能不全组(18例)和心功能正常组(77例),分析需右心室起搏患者发生心功能不全的影响因素。结果:与术后1周比较,术后1年RVAP组感知阈值[(11.51±1.21)mV比(12.11±0.81)mV]显著升高,P=0.004。与RVAP组比较,术后1年RVSP组LVESV[(25.32±7.63)ml比(29.77±12.36)ml]、LVEDV[(58.30±15.71)ml比(68.33±25.31)ml]、SV[(31.36±10.73)ml比(41.29±16.15)ml]均显著升高,LVEF[(60.55±8.76)%比(54.10±6.44)%]及心功能不全比例(27.66%比10.42%)显著降低,P<0.05或<0.01。非条件多因素Logistic回归模型分析显示,LVEF是需右心室起搏患者发生心功能不全的独立保护因素(OR=0.854,P=0.003),而RVAP、年龄≥60岁为其独立危险因素(OR=9.041、4.145,P=0.003、0.024)。结论:与右室心尖部起搏相比,右室间隔部起搏可显著改善每搏量,心功能不全发生率显著降低。Objective:To investigate the changes of left ventricular systolic function in patients after pacing in different sites of right ventricle.Methods:The clinical data of 95 patients requiring right ventricular pacing who were admitted to our hospital from February 2018 to May 2020 were collected.According to pacing site,they were divided into right ventricular apex pacing(RVAP)group(n=47)and right ventricular outflow tract septal pacing(RVSP)group(n=48).The pacing threshold,perception threshold,electrode impedance,left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),stroke volume(SV),left ventricular ejection fraction(LVEF)were compared between the two groups.According to incidence of cardiac insufficiency on one year after pacing,patients were divided into cardiac insufficiency group(n=18)and normal cardiac function group(n=77).Influencing factors of cardiac insufficiency in patients requiring right ventricular pacing were analyzed.Results:Compared with one week after pacing,on one year after pacing,perception threshold[(11.51±1.21)mV vs.(12.11±0.81)mV]significantly increased in RVAP group,P=0.004.Compared with RVAP group on one year after pacing,there were significant rise in LVESV[(25.32±7.63)ml vs.(29.77±12.36)ml],LVEDV[(58.30±15.71)ml vs.(68.33±25.31)ml],SV[(31.36±10.73)ml vs.(41.29±16.15)ml],and significant reductions in LVEF[(60.55±8.76)%vs.(54.10±6.44)%]and proportion of cardiac insufficiency(27.66%vs.10.42%)in RVSP group,P<0.05 or<0.01.Non-conditional multivariate Logistic regression model analysis indicated that LVEF was independent protective factor for cardiac insufficiency in patients requiring right ventricular pacing(OR=0.854,P=0.003),while RVAP and age≥60 years were its independent risk factors(OR=9.041,4.145,P=0.003,0.024).Conclusion:Compared with right ventricular apex pacing,right ventricular outflow tract septal pacing can significantly improve stroke volume,and incidence rate of cardiac insufficiency significantly reduces.

关 键 词：心血管疾病 心脏起搏 人工 左心室收缩功能 

分 类 号：R54[医药卫生—心血管疾病]