重组人生长激素联合注射用醋酸亮丙瑞林对特发性中枢性性早熟患儿生长发育的影响  

Effects of Recombinant Human Growth Hormone Combined with Leuprorelin Acetate for Injection on Growth and Development of Children with Idiopathic Central Precocious Puberty

作　　者：魏泽君 梁静 WEI Zejun;LIANG Jing(Putian Maternal and Child Health Hospital,Putian 351100,China;不详)

机构地区：[1]莆田市妇幼保健院,福建莆田351100

出　　处：《中外医学研究》2024年第15期32-36,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究重组人生长激素(rhGH)联合注射用醋酸亮丙瑞林对特发性中枢性性早熟(ICPP)患儿生长发育的影响。方法:选择2021年1月—2022年8月于莆田市妇幼保健院治疗的86例ICPP患儿作为研究对象。按随机数表法分为两组,各43例。对照组采用注射用醋酸亮丙瑞林治疗,观察组在对照组基础上加用rhGH治疗。比较两组临床效果、性激素水平、生长指标、子宫与卵巢体积及不良反应发生情况。结果:治疗12个月后,两组促黄体生成素(LH)、雌二醇(E2)、卵泡刺激素(FSH)水平低于治疗前,且观察组均低于对照组,差异有统计学意义(P<0.05)。治疗12个月后,两组骨龄差值(ΔBA)低于治疗前,年生长速度、按骨龄的身高标准差分值(HtSDS-BA)、体重指数(BMI)、预测身高(PAH)高于治疗前,而观察组ΔBA低于对照组,年生长速度、HtSDS-BA、PAH高于对照组,差异有统计学意义(P<0.05)。治疗12个月后,两组子宫、卵巢体积小于治疗前,且观察组明显小于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:rhGH联合注射用醋酸亮丙瑞林治疗ICPP患儿效果良好,利于改善患儿性激素水平,延迟骨骼成熟进程,调节患儿生长指标,改善其子宫、卵巢体积,且药物安全性高。Objective:To explore the effects of Recombinant Human Growth Hormone(rhGH)combined with Leuprorelin Acetate for Injection on the growth and development of children with idiopathic central precocious puberty(ICPP).Method:A total of 86 ICPP children treated in Putian Maternal and Child Health Hospital from January 2021 to August 2022 were selected as the study objects.According to the method of random number table,the patients were divided into two groups,with 43 cases in each group.The control group was treated with Leuprorelin Acetate for Injection,the observation group was treated with rhGH on the basis of the control group.The clinical effects,sex hormone levels,growth indexes,uterine and ovarian volumes and occurrence of adverse reactions were compared between the two groups.Result:After 12 months of treatment,the levels of luteinizing hormone(LH),estradiol(E2)and follicle stimulating hormone(FSH)in two groups were lower than those before treatment,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After 12 months of treatment,the bone age difference value(ΔBA)in two groups were lower than those before treatment,annual growth rate,height of bone age standard deviation score(HtSDS-BA),body mass index(BMI),predicted adult height(PAH)were higher than those before treatment,while the ΔBA in the observation group was lower than that in the control group,the annual growth rate,HtSDS-BA and PAH in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).After 12 months of treatment,the volume of uterus and ovary in two groups were smaller than those before treatment,and those in the observation group were significantly smaller than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between two groups(P>0.05).Conclusion:rhGH combined with Leuprelin Acetate for Inj

关 键 词：特发性中枢性性早熟 重组人生长激素 醋酸亮丙瑞林 性激素 

分 类 号：R725.8[医药卫生—儿科]