淫羊藿苷修复骨缺损及其作用机制研究  

Research progress of icariin in repairing bone defect and its mechanism of action

作　　者：杨世超 宋慕格 李幸 王立强 安梓栋 柏鑫 魏振龙 高玉海 陈克明 YANG Shichao;SONG Muge;LI Xing;WANG Liqiang;AN Xindong;BAI Xin;WEI Zhenlong;GAO Yumei;CHEN Keming(Laboratory of Basic Medicine,the 940th Hospital of PLA,Lanzhou 730050,China;Clinical College of Gansu Traditional Chinese Medicine,Lanzhou 730000,China;Key Laboratory of Stem Cell and Gene in Gansu,Lanzhou 730050,China)

机构地区：[1]中国人民解放军联勤保障部队第九四〇医院基础医学实验室,甘肃兰州730050 [2]甘肃中医药大学中医临床学院,甘肃兰州730000 [3]甘肃省干细胞与基因药物重点实验室,甘肃兰州730050

出　　处：《中国骨质疏松杂志》2024年第5期720-724,744,共6页Chinese Journal of Osteoporosis

基　　金：甘肃省自然科学基金项目(22JR5RA020);军队后勤自主科研项目(2023HR22-07);联勤保障部队第九四○医院实验室培育项目(2021yxky081);兰州市科技计划项目(2003-8-1)。

摘　　要：骨缺损治疗一直是困扰骨科的一大难题,由于骨的再生能力有限,大面积的骨缺损常无法自行愈合。淫羊藿苷(icariin,ICA)在骨形成方面的效果明显,淫羊藿含有的ICA是一种黄酮类化合物和活性化合物,具有促进骨形成和抑制骨吸收的双重活性,并且可以通过多种生物材料进行局部递送,促进骨缺损修复,展现出良好的的骨诱导潜力。研究发现,ICA主要通过促进骨形成、软骨形成、血管生成、抑制骨吸收和抗炎作用修复骨缺损。本文就ICA修复骨缺损及其作用机制加以概述,以期为后续研究提供一定参考。The treatment of bone defects has always been a major problem in orthopedics.Due to the limited regenerative capacity of bone,large-scale bone defects often cannot be healed by themselves.Icariin(ICA)has an obvious effect on bone formation.ICA contained in Icariin is a flavonoid compound and an active compound,which has dual activities of promoting bone formation and inhibiting bone absorption.Icariin can also be delivered locally through a variety of biological materials to promote bone defect repair,showing a good bone induction potential.It has been found that ICA mainly repairs bone defects by promoting bone formation,cartilage formation,angiogenesis,and by inhibiting bone resorption and anti-inflammatory effects.In this paper,ICA repair of bone defect and its mechanism of action are summarized in order to provide some reference for the follow-up research.

关 键 词：淫羊藿苷 骨缺损 成骨细胞 骨形成 作用机制 

分 类 号：R285[医药卫生—中药学] R274.1[医药卫生—中医学]