肠道菌群-胆汁酸在骨质疏松骨代谢紊乱中的研究  

Research on gut microbiota-bile acid in bone metabolism disorder of osteoporosis

作　　者：陈宇航 许云腾 张欣 梁辉强 卓俊宽 王珊珊 CHEN Yuhang;XU Yunteng;ZHANG Xin;LIANG Huiqiang;ZHUO Junkuan;WANG Shanshan(School of Integrated Traditional Chinese and Western Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;College of Integrative Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China)

机构地区：[1]福建中医药大学中西医结合学院,福建福州350122 [2]福建中医药大学中西医结合研究院,福建福州350122

出　　处：《中国骨质疏松杂志》2024年第5期761-767,共7页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(82304899);福建省自然科学基金面上项目(2021J01893);福建中医药大学高层次人才引进项目(X2020011-人才)。

摘　　要：骨质疏松症是常见的骨代谢疾病之一,其发病机制涉及广泛且复杂的相互作用。骨质疏松症的发生发展与肠道菌群失调和胆汁酸水平改变存在密切联系。肠道菌群能通过免疫、内分泌等机制调节骨代谢,亦能代谢生成次级胆汁酸进而重塑胆汁酸池。胆汁酸作为肠道菌群的一种代谢产物,可通过结合多种胆汁酸受体参与调节骨代谢,亦可逆向影响肠道菌群结构。本文从系统生物学的角度出发并详细阐述肠道菌群、胆汁酸与骨质疏松症之间的内在联系、肠道菌群和胆汁酸的互作特点以及肠道菌群-胆汁酸失衡对骨质疏松症的影响,旨在为骨质疏松症的防治提供新思路。Osteoporosis is a common bone metabolism disorder,and its pathogenesis involves extensive and complex interactions.There is a close association between dysbiosis of the gut microbiota and changes in bile acid levels with the development of osteoporosis.The gut microbiota can modulate bone metabolism through immune and endocrine mechanisms and can also metabolize and generate secondary bile acids to reshape the bile acid pool.Bile acids,as a metabolic product of the gut microbiota,can regulate bone metabolism by binding to various bile acid receptors and can also reversely impact the structure of the gut microbiota.Starting from a systems biology perspective,this article elaborates on the intrinsic connections between the gut microbiota,bile acids,and osteoporosis,as well as the interactive characteristics of the gut microbiota and bile acids.It also discusses the influence of gut microbiota-bile acid imbalance on osteoporosis,aiming to provide new insights for the prevention and treatment of osteoporosis.

关 键 词：骨质疏松症 肠道菌群 胆汁酸 骨代谢 

分 类 号：R589[医药卫生—内分泌]