2017—2021年四川省手足口病流行病学和病原学特征分析  

Epidemiological and etiological characteristics of hand foot and mouth disease,Sichuan,2017-2021

作　　者：刘雅琼[1] 童文彬[1] 马小珍[1] 速丽媛[2] 张朝勇 张洁[4] 包莹 漆琪[1] 刘伦光[1] 袁珩[1] LIU Ya-qiong;TONG Wen-bin;MA Xiao-zhen;SU Li-yuan;ZHANG Chao-yong;ZHANG Jie;BAO Yin;QI Qi;LIU Lun-guang;YUAN Heng(Institute for Acute Infectious diseases Control and Prevention,Sichuan Center for Disease Control and Prevention,Chengdu,Sichuan 610041,China)

机构地区：[1]四川省疾病预防控制中心,四川成都610041 [2]成都市疾病预防控制中心 [3]成都市公共卫生临床医疗中心 [4]自贡市疾病预防控制中心

出　　处：《现代预防医学》2024年第10期1742-1747,共6页Modern Preventive Medicine

基　　金：四川省疾病预防控制中心自立课题(ZX201802);中央补助重大疾病与健康危害因素监测项目(川财社[2020]208号)。

摘　　要：目的分析2017—2021年四川省手足口病流行特征,为科学防控提供依据。方法从中国疾病预防控制中心“疾病监测信息报告管理系统”中下载2017—2021年四川省手足口病个案资料,采用描述性流行病学方法分析。结果2017—2021年四川省累计报告手足口病442079例,发病率106.17/10万;重症病例627例,死亡病例4例。病例以5岁以下儿童为主,占病例总数的90.99%。男女性别比为1.35:1。散居儿童占病例总数的63.34%。除个别年份外,每年有两个发病高峰,春夏高峰为4—7月,秋冬高峰为11—12月。成都平原及周边地区发病水平较高。2017—2021年病原学构成以其他肠道病毒(非肠道病毒71型和柯萨奇病毒A16型)为主,比例为71.45%;柯萨奇病毒A16型和肠道病毒71型的比例分别为21.20%和7.35%。结论2017—2021年四川省手足口病发病水平高,重症病例比例大幅下降(χ_(趋势)^(2)=273.241,P<0.001)、主要流行毒株为非肠道病毒71型和柯萨奇病毒A16型的其他肠道病毒。Objective To analyze the epidemic characteristics of hand foot and mouth disease(HFMD)in Sichuan province from 2017 to 2021 and to provide evidence for prevention and control.Methods A descriptive analysis was conducted by downloading the case-data of HFMD in Sichuan province during 2017 to 2021 from the Chinese National Notifiable Infectious Disease Reporting System.Results A total of 442079 cases of HFMD were reported from 2017 to 2021,including 627 severe cases and 4 deaths.The average annual incidence rate was 106.17/100000.Cases in children aged 5 or younger accounted for 90.99%.Boys had higher incidence than girls(1.35:1).The scattered children accounted for 63.34%.Two peaks of incidence were observed other years,except for a few years,with the highest occurring between April to July and the second occurring in November to December.The incidence in Chengdu plain and its surrounding areas were significantly higher than other regions.Other enteroviruses(non-enterovirus 71 and Coxsackie virus A16)were the main pathogen,accounting for 71.45%;Coxsackie virus A16 accounted for 21.20%and enterovirus 71 accounted for 7.35%.Conclusion The incidence of HFMD in Sichuan Province is high from 2017 to 2021.The proportion of severe cases has significantly decreased(χ^(2)=273.241,P<0.001),and the main pathogen is the other enteroviruses(non-enterovirus 71 and Coxsackie virus A16).

关 键 词：手足口病 流行病学 肠道病毒 

分 类 号：R181.3[医药卫生—流行病学] R725.1[医药卫生—公共卫生与预防医学]