肿瘤微环境中髓样细胞调控肝细胞癌发生、发展的研究进展  

Research progress of the regulation of myeloid cells in the tumor microenvironment on the occurrence and development of hepatocellular carcinoma

作　　者：罗佳佳 廖长秀 LUO Jia-jia;LIAO Zhang-xiu(College of Pharmacy,Youjiang Medical University for Nationalities,Baise 533000,China;College of Basic Medical Sciences,Youjiang Medical University for Nationalities,Baise 533000,China)

机构地区：[1]右江民族医学院药学院,百色533000 [2]右江民族医学院基础医学院,百色533000

出　　处：《现代免疫学》2024年第3期275-280,共6页Current Immunology

基　　金：国家自然科学基金(81660642);2022年度广西学位与研究生教育改革课题(JGY2022278)。

摘　　要：肿瘤微环境(tumor microenvironment,TME)是一个存在于肿瘤细胞周围的复杂的细胞环境。由肿瘤细胞、免疫细胞和基质细胞构成,在肿瘤发生中起着至关重要的作用。在肿瘤浸润的免疫细胞中,特别是髓样细胞[主要包括肿瘤相关巨噬细胞(tumor-associated macrophage,TAM)、肥大细胞(mast cell,MC)、DC、肿瘤相关中性粒细胞(tumor-associated neutrophil,TAN)和骨髓源性抑制细胞(myeloid-derived suppressor cell,MDSC)]在数量和功能上都是一个突出的组成部分,可以影响肿瘤的生长、侵袭、转移和死亡,具有促癌与抑癌的复杂的双重调节作用。该文对TME中多种髓样细胞调控肝细胞癌(hepatocellular carcinoma,HCC)发生、发展的进展进行综述。The tumor microenvironment(TME)is a complex cellular environment around tumor consisting of tumor cells,immune cells,and stromal cells,which plays a crucial role in tumorigenesis.Among tumor-infiltrated immune cells,a major composition and functional significant population is the myeloid cells(including tumor-associated macrophage[TAM],mast cell[MC],DC,tumor-associated neutrophil[TAN],and myeloid-derived suppressor cell[MDSC]).They have a complex dual regulatory role in both cancer promotion and suppression and affect tumor growth,invasion,metastasis,and death.This review focuses on the research progress of how multiple myeloid cells in the TME regulate the occurrence and development of hepatocellular carcinoma(HCC).

关 键 词：肿瘤微环境 髓样细胞 肝细胞癌 发生 发展 

分 类 号：R392.11[医药卫生—免疫学]