心肌缺血再灌注损伤大鼠HMGB1表达水平的Meta分析  

Expression levels of HMGB1 in rats with myocardialischemia-reperfusion injury: a meta-analysis

作　　者：岑团 刘燕[1] 黄照河 CEN Tuan;LIU Yan;HUANG Zhaohe(Department of Cardiovascular Medicine,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China;Graduate School,Youjiang Medical University for Nationalities Graduate School,Baise 533000,Guangxi,China)

机构地区：[1]右江民族医学院附属医院心血管内科,广西百色533000 [2]右江民族医学院研究生学院,广西百色533000

出　　处：《右江医学》2024年第5期451-458,共8页Chinese Youjiang Medical Journal

基　　金：国家自然科学基金(82260883);广西自然科学基金(2020GXNSFAA297102)。

摘　　要：目的对心肌缺血再灌注损伤(MIRI)大鼠高迁移率族蛋白B1(HMGB1)表达水平进行Meta分析。方法在PubMed、Embase及中国国家知识基础设施(CNKI)数据库检索相关文章,最终共纳入16篇文献,从这些文章中提取假手术组、模型组、预处理组的样本量、均数和标准差,采用SYRCLE动物实验风险评估工具进行方法学质量评价,应用Stata12.0软件进行Meta分析。结果MIRI大鼠模型组HMGB1表达水平显著高于假手术组(SMD=8.66,95%CI:6.49~10.82,P<0.001),MIRI大鼠预处理组HMGB1表达水平明显低于模型组(SMD=-3.33,95%CI:-4.22~-2.44,P<0.001)。亚组分析表明,不同预处理方式可能导致异质性存在。敏感性分析显示Meta分析结果可信度较高,而漏斗图显示存在发表偏倚。结论MIRI大鼠HMGB1表达水平升高,通过治疗可降低MIRI大鼠HMGB1表达水平。Objective To conduct a meta-analysis on the expression levels of high mobility group box1(HMGB1)in rats with myocardial ischemia reperfusion injury(MIRI).Methods Relevant articles were searched in PubMed,Embase and China National Knowledge Infrastructure(CNKI)databases,and a total of 16 articles were finally included.Sample size,mean and standard deviation of sham operation group,model group and pretreatment group were extracted from these articles.SYRCLE animal experiment risk assessment tool was used for methodological quality evaluation,and Stata12.0 software was used for meta analysis.Results The expression levels of HMGB1 in the MIRI rat model group were significantly higher than those in the sham operation group(SMD=8.66,95%CI:6.49-10.82,P<0.001).The expression levels of HMGB1 in the MIRI rat pretreatment group were significantly lower than those in the model group(SMD=-3.33,95%CI:-4.22 to-2.44,P<0.001).Subgroup analysis showed that different pretreatment methods might lead to heterogeneity.Sensitivity analysis showed that meta-analysis results were more reliable,while funnel plot showed a existence of publication bias.Conclusion The expression levels of HMGB1 in MIRI rats are increased,and treatment can reduce the expression levels of HMGB1 in MIRI rats.

关 键 词：心肌缺血再灌注损伤 高迁移率族蛋白B1 预处理 META分析 

分 类 号：R542.2[医药卫生—心血管疾病]