过渡金属催化C—S键活化与转化研究进展  

Recent Advances in Transition-Metal-Catalyzed C—S Bond Activation and Transformations

作　　者：郭凯杰 符昕姝 李靖[1] 陈艳[1] 胡美丽[1] 堵锡华[1] 谢屿阳 何燕 Guo Kaijie;Fu Xinshu;Li Jing;Chen Yan;Hu Meili;Du Xihua;Xie Yuyang;He Yan(School of Materials and Chemical Engineering,Xuzhou University of Technology,Xuzhou,Jiangsu 221018;Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy,Xuzhou Medical University,Xuzhou,Jiangsu 221004)

机构地区：[1]徐州工程学院材料与化学工程学院,江苏徐州221018 [2]徐州医科大学江苏省新药研究与临床药学重点实验室,江苏徐州221004

出　　处：《有机化学》2024年第4期1124-1150,共27页Chinese Journal of Organic Chemistry

基　　金：徐州市科技计划(No.KC21286);2022年徐州工程学院“大创计划”(No.xcx2022013)资助项目。

摘　　要：C—S键的活化,对于药物分子、高性能聚合物和复合材料的制备以及生物医学、环境保护等领域具有重要作用,过渡金属催化C—S键的活化与转化更是具有广泛的应用前景.根据有机硫化物中碳原子的杂化类型进行分类,综述了近十年来过渡金属催化C(sp)/C(sp^(2))/C(sp^(3))—S键活化与转化的研究进展,采用不同的过渡金属催化剂,着重讨论了底物适用性和反应机理,并对该领域存在的挑战以及未来发展趋势进行了讨论和展望.The activation of C—S bond plays a crucial role in the preparation of drug molecules,high-performance polymers and composite materials,as well as in biomedical,environmental protection and other fields.Transition-metal-catalyzed C—S bond activation and transformations have a wide range of application prospects.Herein,the recent advances in transition-metal-catalyzed C(sp)/C(sp^(2))/C(sp^(3))—S bond activation and transformations are summarized according to the hybridization types of carbon atoms in organosulfur compounds.Various transition metal catalysts are utilized.The substrate applicability and reaction mechanisms are emphatically discussed.Finally,the challenges and future development trends of this research field are discussed and prospected.

关 键 词：C—S键活化 过渡金属催化 有机硫化物 

分 类 号：O621.251[理学—有机化学]