三氟甲硫基自由基引发涉及烯烃、AgSCF_(3)和喹喔啉酮的三组分反应  

Three-Component Reaction Involving Alkenes,AgSCF_(3) and Quinoxalinones Initiated by Trifluoromethylthio Radical

作　　者：高燊原 诸昊穹 金巧玲[1] 金露儿 王晓钟[1] 戴立言[1] Gao Shenyuan;Zhu Haoqiong;Jin Qiaoling;Jin Lu'er;Wang Xiaozhong;Dai Liyan(Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310027)

机构地区：[1]浙江大学化学与生物工程学院浙江省先进化工制造技术重点实验室,杭州310027

出　　处：《有机化学》2024年第4期1264-1275,共12页Chinese Journal of Organic Chemistry

基　　金：浙江省先进化工制造技术重点实验室(No.2017E10001)资助项目。

摘　　要：提出了一种新的非活化烯烃、喹喔啉酮和AgSCF_(3)的三组分级联自由基反应.在氧化剂K_(2)S_(2)O_(8)的作用下,得到了40个含SCF_(3)的喹喔啉酮类衍生物,其中产率最高至78%.该方法是一种在温和条件下制备含三氟甲硫基喹唑啉酮类化合物,具有产率高、底物范围广、原子经济性高和环保高效等优势.A novel three-component cascade radical reaction involving non-activated olefins,quinoxalin-2(1H)-ones,and AgSCF_(3) was proposed.Under the action of the oxidizing agent K_(2)S_(2)O_(8),40 quinoxaline derivatives containing SCF3 were obtained with the highest yield of 78%.This method provides a mild and environmentally friendly approach to prepare trifluoromethylthio-substituted quinoxalines,offering advantages such as high yield,broad substrate scope,atom economy,and environmental efficiency.

关 键 词：三氟甲烷硫醇银 自由基 三组分反应 

分 类 号：O626[理学—有机化学]