无催化剂和无添加剂条件下直接合成N-磺酰基胍类化合物  

Catalyst-and Additive-Free Direct Synthesis of N-Sulfonyl Guanidines

作　　者：麦尔哈巴·居来提 布鲁努尔·玉散 阿不都热合曼·乌斯曼[1,2] Maierhaba Julaiti;Bulunuer Yusan;Abudureheman Wusiman(School of Chemistry and Chemical Engineering,Xinjiang Normal University,Urumqi 830054;Xinjiang Key Laboratory of Energy Storage and Photoelectrocatalytic Materials,Urumqi 830054)

机构地区：[1]新疆师范大学化学化工学院,乌鲁木齐830054 [2]新疆储能与光电催化材料重点实验室,乌鲁木齐830054

出　　处：《有机化学》2024年第4期1276-1283,共8页Chinese Journal of Organic Chemistry

基　　金：新疆维吾尔自治区自然科学基金(No.2021D01A115);新疆储能及光电催化材料重点实验室(No.XJDX1709-2022-02)资助项目。

摘　　要：报道了一种在无催化剂和无添加剂条件下,以磺酰胺和碳二亚胺为原料直接合成N-磺酰基胍类化合物的方法.该方法无需催化剂和添加剂,操作简单,官能团兼容性良好,底物适用范围广,产率高,具有较高的原子经济性以及可按比例放大等优点,为N,N',N''-三取代磺酰胍类化合物的合成提供了一种简单、有效的途径.A simple and direct method for the synthesis of N-sulfonyl guanidines from sulfonamide and carbodiimides under catalyst-and additive-free conditions was demonstrated.This method has the advantages of no catalyst and additive required,simple operation,good functional group compatibility,a wide range of substrate applications,high yield,high atomic economy,and the ability to scale up proportionally.It provides a facile and efficient strategy for the preparation of N,N',N''-trisub-stituted sulfonyl guanidines.

关 键 词：磺酰胍 磺酰胺 碳二亚胺 无催化剂 无添加剂 

分 类 号：O621.3[理学—有机化学]