矮陀陀中一个新的脂肪酸苷类化合物  

A New Fatty Acid Glycoside Compound in Munronia Pinnata

作　　者：刘培源 韦玉璐 宋静茹[2] 颜小捷[2] 卢凤来 陈月圆 羊学荣 李典鹏[2,3] Liu Peiyuan;Wei Yulu;Song Jingru;Yan Xiaojie;Lu Fenglai;Cheng Yueyuan;Yang Xuerong;Li Dianpeng(School of Pharmacy,Guilin Medical University,Guilin,Guangxi 541004;Guangxi Key Laboratory of Plant Functional Phytochemicals and Sustainable Utilization,Guangxi Institute of Botany,Guangxi Zhuang Autonomous Region and Chinese Academy Sciences,Guilin,Guangxi 541006;Engineering Research Center of Innovative Traditional Chinese,Zhuang and Yao Materia Medica,Ministry of Education,Guangxi University of Chinese Medicine,Nanning,Guangxi 530200)

机构地区：[1]桂林医学院药学院,广西桂林541004 [2]广西壮族自治区中国科学院、广西植物研究所广西植物功能物质与资源持续利用重点实验室,广西桂林541006 [3]广西中医药大学、中药壮瑶药创新药物教育部工程研究中心,广西南宁530200

出　　处：《有机化学》2024年第4期1348-1356,共9页Chinese Journal of Organic Chemistry

基　　金：广西自然科学基金(No.2020GXNSFBA297055);广西科技基础条件与人才计划(No.桂科AA21196009);国家重点研发项目(No.2022YFD1600302);国家自然科学基金(No.U20A2004);广西科学院基础研究基金(No.CQZ-C-1901);桂林创新平台与人才计划(No.20210102-3);广东省重点领域研究发展计划(No.2020B1111110003)资助项目。

摘　　要：采用多种色谱分离技术对楝科(Meliaceae)地黄连属(Munronia)羽状地黄连(Munronia pinnata W.Theobald)(矮陀陀)的地上部分进行化学成分研究,从其95%乙醇部分中分离得到10个化合物,并通过MS、IR、1D-和2D-NMR等谱学手段和量子化学计算方法等技术手段对其结构进行了鉴定,分别为矮陀陀脂肪酸苷A(1)、2-[6-O-((2E)-6R-羟基-2,6-二甲基-2,7-辛二烯基)-β-D-吡喃葡萄糖基]-2-甲基乳酸氧苷(2)、山奈酚-3-O-(6''-O-反式对香豆酰基)-β-D-吡喃葡萄糖苷(3)、栗苷A(4)、山奈酚-3-O-(6''-O-顺式对香豆酰基)-β-D-吡喃葡萄糖苷(5)、金色酰胺醇酯(6)、布卢门醇A(7)、蚱蜢酮(8)、curcusinol(9)和黑麦草素内脂(10).其中化合物1为新化合物,化合物2的NMR数据为首次报道.生物活性筛查显示化合物1在160μmol/L的浓度下对HCT116、A549、HepG2、MCF7和MDAMB等肿瘤细胞均无细胞毒性作用.The chemical constituents of the aerial parts of Munronia pinnata W.Theobald were investigated by using chro-matographic techniques.Ten compounds were isolated from the 95%ethanol extract of Munronia pinnata.Their structures were identified as munrofatty A(1),2-[[6-O-((2E)-6R-hydroxy-2,6-dimethyl-2,7-octadienoyl)-β-D-glucopyranosyl]oxy]-2-methylpropanoic acid(2),kaempferol-3-O-(6-O-trans-p-coumaroyl)-β-D-glucopyranoside(3),castanoside A(4),kaempferol-3-O-(6''-O-cis-pcoumaroyl)-β-D-glucopyranoside(5),aurantiamide acetate(6),blumenol A(7),grasshopper ketone(8),curcusinol(9)and loliolide(10)through detailed analyses of various technical means,including MS,IR,1D-and 2D-NMR spectroscopic methods,quantum calculation methods and other technical means.Compound 1 is a new compound,while NMR data of compound 2 are presented for the first time.Compound 1 was evaluated for cytotoxicity against HCT116,A549,HepG2,MCF7 and MDAMB cells,and was non-toxic to the tested cells at a concentration of 160μmol/L.

关 键 词：楝科 矮陀陀 矮陀陀脂肪酸苷A 结构鉴定 

分 类 号：R284.1[医药卫生—中药学]