土坛树中高度氧化的杜松烷型倍半萜及其生物活性研究  

Studies on the Highly Oxidized Cadinane Sesquiterpenes from Alangium salviifolium and Their Bioactivities

作　　者：魏艳梅 余章昕[1,2] 杜怡益 王平淑 岑福凌 李小宝[1,2] 陈光英[1,2] Wei Yanmei;Yu Zhangxin;Du Yiyi;Wang Pingshu;Cen Fuling;Li Xiaobao;Chen Guangying(Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education,Hainan Normal University,Haikou 571158;Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province,College of Chemistry and Chemical Engineering,Hainan Normal University,Haikou 571158)

机构地区：[1]海南师范大学热带药用资源化学教育部重点实验室,海口571158 [2]海南师范大学化学与化工学院、海南省热带药用植物化学重点实验室,海口571158

出　　处：《有机化学》2024年第4期1363-1367,共5页Chinese Journal of Organic Chemistry

基　　金：海南省重点研发项目(Nos.ZDYF2022SHFZ286,ZDYF2021SHFZ072);国家自然科学基金(No.21662012);海南省院士创新平台(No.YSPTZX202030);中央引导地方科技发展专项(No.ZY2022HN08);海南师范大学“大学生创新创业训练计划”(No.202311658005)资助项目。

摘　　要：从海南民间药用植物土坛树树皮中分离得到2个新的高度氧化的杜松烷型倍半萜类化合物alansalene A(1)和2,7-二羟基-4-异丙基-1-甲基-6-萘醛(5)以及5个已知的同系物,通过NMR、HR-ESI-MS等多种现代波谱技术确定了其化学结构.体外抗炎活性显示,化合物alangene D(2)具有突出的抗炎活性,其IC_(50)=(2.98±0.11)μmol/L强于阳性对照药物地塞米松[IC_(50)=(39.62±0.12)μmol/L].体外α-葡萄糖苷酶抑制活性显示,化合物alangene F(3)和2,7-二羟基-4-异丙基-6-甲基萘-1-甲醛(6)表现出强的α-葡萄糖苷酶抑制活性,其IC_(50)值为分别为(111.85±1.80)和(18.55±0.68)μmol/L[阳性对照阿卡波糖IC_(50)=(478.75±27.14)μmol/L].Two new highly oxidized cadinane sesquiterpenes of alansalene A(1)and 2,7-dihydroxy-4-isopropyl-1-methyl-6-naphthaldehyde(5),and five known analogues were isolated from the barks of Alangium salviifolium,which is a folk medicinal plant in Hainan.The structures were elucidated by spectroscopic methods(1D and 2D NMR,HR-ESI-MS).Compound alangene D(2)exhibited stronger anti-inflammatory activity in vitro with IC_(50) value of(2.98±0.11)μmol/L to that of dexamethasone[IC_(50)=(39.62±0.12)μmol/L].Alangene F(3)and 2,7-dihydroxy-4-isopropyl-6-methylnaphthalene-1-carbaldehyde(6)displayed potentialα-glucosidase inhibitory activities with IC_(50) values of(111.85±1.80)and(18.55±0.68)μmol/L,respectively,which were stronger than that of acarbose[IC_(50)=(478.75±27.14)μmol/L].

关 键 词：土坛树 高度氧化 倍半萜 抗炎 α-葡萄糖苷酶抑制 

分 类 号：R284.1[医药卫生—中药学] TQ28[医药卫生—中医学]