电化学芳烃C(sp^(2))—H胺化反应的研究进展  

Recent Advance in Electrochemical C(sp^(2))-H Amination of Arenes

作　　者：朱子乐 李鹏飞[1] 仇友爱 Zhu Zile;Li Pengfei;Qiu Youai(State Key Laboratory and Institute of Elemento-Organic Chemistry,College of Chemistry,Nankai University,Tianjin 300071)

机构地区：[1]南开大学化学学院元素有机化学国家重点实验室,天津300071

出　　处：《有机化学》2024年第3期871-891,共21页Chinese Journal of Organic Chemistry

基　　金：Project supported by the National Key Research and Development Program of China(No.2022YFA1503200);the National Natural Science Foundation of China(Nos.22371149,22188101);the Fundamental Research Funds for the Central Universities(No.63223015);the Frontiers Science Center for New Organic Matter,Nankai University(No.63181206)。

摘　　要：苯胺及其衍生物在人类生活和工业生产中被广泛地使用,促使人们探索从相应的C(sp2)—H键直接构建芳香C(sp^(2))—N键的反应方法.近年来,有机电化学作为一种可控、可持续、环境友好和易于扩展规模的方法,受到越来越多的关注,同时也为芳烃的胺化提供了新的反应模式.在此篇综述中,总结了电化学芳香族C(sp^(2))—H胺化反应中常见的机理途径,根据所涉及的胺源类型对反应实例进行了分类,并对该领域的前景和挑战提供了见解.Aniline and its derivatives are widely used and consumed in human life and industrial production,which inspires the direct aromatic C(sp2)—N construction from the corresponding C(sp2)—H bond.In recent years,as a controllable,sustainable,ambient,and highly scalable methodology,organic electrochemistry has received greater attention and also combined aromatic C(sp^(2))—N amination,presenting novel reactions.In this review,the common mechanism manifolds of electrochemical aromatic C(sp^(2))—H amination reactions are summarized,and the reactions examples are classified according to the type of amine sources.The prospects and challenges in this field are provided.

关 键 词：电化学 胺化 芳烃 苯胺 C—H键胺化 

分 类 号：O625.1[理学—有机化学] O621.255.9[理学—化学]