电化学促进未活化C(sp^(3))—H官能团化研究进展  

Recent Advances in Electrochemical-Promoted Unactivated C(sp^(3))-H Functionalization

作　　者：高瑞林 文丽荣[1] 郭维斯[1] Gao Ruilin;Wen Lirong;Guo Weisi(College of Chemistry&Molecular Engineering,Qingdao University of Science&Technology,Qingdao,Shandong 266042)

机构地区：[1]青岛科技大学化学与分子工程学院,山东青岛266042

出　　处：《有机化学》2024年第3期892-902,共11页Chinese Journal of Organic Chemistry

基　　金：山东省自然科学基金(No.ZR2020MB005)资助项目。

摘　　要：有机电合成以无痕电子代替传统的化学氧化剂或还原剂,具有绿色易放大等优势.未活化C(sp^(3))—H键的官能团化可以将目标官能团直接引入分子中进行修饰,避免预官能团化,兼具原子经济性和步骤经济性.随着有机电合成发展的日益成熟,电化学促进未活化C(sp^(3))—H官能团化成为了有机合成的研究热点之一.根据官能团类型对反应进行分类,总结了近年来涉及未活化C(sp^(3))—H官能化的研究成果,重点分析了反应优势、底物特点以及反应机理,最后展望了面临的挑战及未来的发展趋势.Organic electrosynthesis replaces traditional chemical oxidants or reductants with traceless electrons,which has the advantages of sustainability and easy to scale up.The functionalization of unactivated C(sp^(3))—H bond can directly introduce the target functional group into the molecules,avoiding pre-functionalization and possessing both atomic and step economies.With the development of organic electrosynthesis,electrochemical-promoted functionalization of unactivated C(sp^(3))—H bond has become one of the hotspots in organic synthesis.The functional groups are classified according to the types of functional groups,and the recent achievements related to the functionalization of unactivated C(sp^(3))—H bond are summarized,with emphasis on analyzing reaction advantages,substrate scope,and reaction mechanism.Finally,the current challenges and future development are briefly discussed.

关 键 词：有机电合成 未活化C(sp^(3))—H键 官能团化 

分 类 号：O621.3[理学—有机化学]