以路易斯碱硼烷为氢供体电催化还原喹啉及酮  

Electrocatalytic Reduction of Quinolines and Ketones by Using Lewis Base-Ligated Borane as a Hydrogen Donor

作　　者：陈红斌 杨思佳 叶智鹏 陈凯 向皞月 阳华[1] Chen Hongbing;Yang Sijia;Ye Zhipeng;Chen Kai;Xiang Haoyue;Yang Hua(College of Chemistry and Chemical Engineering,Central South University,Changsha 410083)

机构地区：[1]中南大学化学化工学院,长沙410083

出　　处：《有机化学》2024年第3期966-971,共6页Chinese Journal of Organic Chemistry

基　　金：supported by the National Natural Science Foundation of China(Nos.22078370,22078369,22003077);the Basic Science Center Project for National Natural Science Foundation of China(No.72088101);the Natural Science Foundation of Hunan Province(Nos.2022JJ20055,2020JJ4682)。

摘　　要：以路易斯碱-硼烷络合物(LB-BH3)为氢供体,开发了一种通用的、直接的喹啉电化学还原策略,从而快速获得多种具有生物活性的1,2,3,4-四氢喹啉类化合物.此外,该方法还被成功地应用于其他双键的还原,包括C=O,N=N和C=C.该方法具有操作简单、反应条件温和及底物范围广等特点.By employing Lewis base-ligated boranes(LB-BH3)as the hydrogen donor,a general and straightforward electrochemical protocol for transfer hydrogenation of quinoline was developed to access a variety of bioactive 1,2,3,4-tetrahydroquinolines.Moreover,this developed protocol was successfully applied to the reduction of other double bonds,including C=O,N=N and C=C bonds.This method has some characteristics such as simple operation,mild reaction conditions and a wide range of substrates.

关 键 词：硼烷 电化学 还原 1 2 3 4-四氢喹啉类 

分 类 号：O626.323[理学—有机化学]