N-苄基丙烯酰胺的电化学三氟甲基化/螺环化合成三氟甲基取代2-氮杂螺[4.5]癸烷  

Electrochemical Trifluoromethylation/Spirocyclization of N-Benzylacrylamides to Construct Trifluoromethylated 2-Azaspiro[4.5]decanes

作　　者：周兰 何红 杨德巧 侯中伟 王磊 Zhou Lan;He Hong;Yang De-Qiao;Hou Zhong-Wei;WangLei(Advanced Research Institute,School of Pharmaceutical Sciences,Taizhou University,Taizhou,Zhejiang 318000;College of Material Chemistry and Chemical Engineering,Key Laboratory of Organosilicon Chemistry and Material Technology,Ministry of Education,Hangzhou Normal University,Hangzhou 311121;State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032)

机构地区：[1]台州学院高等研究院药学院,浙江台州318000 [2]杭州师范大学材料与化学化工学院、有机硅化学及材料技术教育部重点实验室,杭州311121 [3]中国科学院上海有机化学研究所、金属有机化学国家重点实验室,上海200032

出　　处：《有机化学》2024年第3期981-988,共8页Chinese Journal of Organic Chemistry

基　　金：Project supported by the National Natural Science Foundation of China(Nos.22071171,22101201);the Natural Science Foundation of Zhejiang Province(Nos.LZ22B020003,LQ22B020005)。

摘　　要：利用CF_(3)SO_(2)Na作为三氟甲基来源,开发了N-苄基丙烯酰胺的电化学三氟甲基化/螺环化反应.该方法在室温下于一个简单未分室电解池中进行,无需依赖金属试剂和氧化剂,为构建系列三氟甲基取代2-氮杂螺[4.5]癸烷提供了绿色和高效的路径.此外,反应易进行克级合成和转化.An electrochemical trifluoromethylation/spirocyclization of N-benzylacrylamides with CF_(3)SO_(2)Na as the source of trifluoromethyl group has been developed.This approach is carried out in a simple undivided cell at room temperature without relying on metal-reagents and oxidants,which provides a green and efficient route to construct a series of CF3-containing 2-azaspiro[4.5]decanes.Furthermore,the gram-scale synthesis and transformation can be easily performed.

关 键 词：有机电化学 三氟甲基化 螺环化 螺环产物 

分 类 号：O626[理学—有机化学]