Engineering vascularized organotypic tissues via module assembly  

作　　者：Zhenzhen Zhou Changru Liu Yuting Guo Yuan Pang Wei Sun 

机构地区：[1]Biomanufacturing Center,Department of Mechanical Engineering,Tsinghua University,Haidian District,Beijing 100084,People’s Republic of China [2]Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing,Beijing 100084,People’s Republic of China [3]Key Laboratory for Advanced Materials Processing Technology,Ministry of Education,Beijing 100084,People’s Republic of China [4]Department of Mechanical Engineering,Drexel University,Philadelphia,PA 19104,United States of America

出　　处：《International Journal of Extreme Manufacturing》2024年第1期155-175,共21页极端制造（英文）

摘　　要：Adequate vascularization is a critical determinant for the successful construction and clinical implementation of complex organotypic tissue models. Currently, low cell and vessel density and insufficient vascular maturation make vascularized organotypic tissue construction difficult,greatly limiting its use in tissue engineering and regenerative medicine. To address these limitations, recent studies have adopted pre-vascularized microtissue assembly for the rapid generation of functional tissue analogs with dense vascular networks and high cell density. In this article, we summarize the development of module assembly-based vascularized organotypic tissue construction and its application in tissue repair and regeneration, organ-scale tissue biomanufacturing, as well as advanced tissue modeling.

关 键 词：vascularized organotypic tissue module assembly regenerative medicine tissue engineering 

分 类 号：R318.08[医药卫生—生物医学工程]