血管内皮功能障碍运动干预的血流剪切力作用机制研究进展  

Research Progress on the Mechanisms of Wall Shear Stress in Exercise Intervention for Vascular Endothelial Dysfunction

作　　者：时文霞 谢军[2] 何玉凤 李旭龙[4] 白爽 韩晓伟 唐东辉[1] SHI Wenxia;XIE Jun;HE Yufeng;LI Xulong;BAI Shuang;HAN Xiaowei;TANG Donghui(Beijing Normal University,Beijing 100875,China;Capital University of Physical Education and Sports,Beijing 100191,China;Nanfang College Guangzhou,Guangzhou 510970,China;Qingdao University of Technology,Qingdao 266520,China)

机构地区：[1]北京师范大学,北京100875 [2]首都体育学院,北京100191 [3]广州南方学院,广东广州510970 [4]青岛理工大学,山东青岛266520

出　　处：《中国体育科技》2024年第3期51-64,共14页China Sport Science and Technology

基　　金：国家自然科学基金项目(71874017)。

摘　　要：血管内皮功能障碍是心血管疾病发生发展的初始环节,血流剪切力是影响血管内皮的重要血管力学因素,在维护血管内皮功能中发挥重要作用。血流剪切力能够激活下游信号转导、基因和蛋白质表达,直接影响内皮细胞形态、代谢和炎症表型,促进血管内皮功能障碍的发生和发展。运动作为一种非临床干预疗法可以产生不同程度的血流刺激,对血管内皮功能产生积极作用。研究通过综述血管内皮功能障碍的产生、血管内皮功能运动适应和血流剪切力之间的量效关系及其相关分子机制,总结了不同方式、时间和强度的运动在改善血管内皮功能障碍中的独特血流剪切力作用特点。Vascular endothelial dysfunction is the initial link in the development of cardiovascular diseases.Wall shear stress is an important vascular mechanical factor that plays an important role in maintaining vascular endothelial function.Wall shear stress can activate downstream signal transduction,as well as gene and protein expression,thereby directly affecting endothelial cell morphology,metabolism and inflammatory phenotype,and promoting the occurrence and development of vascular endothelial dysfunction.Exercise,as a non-clinical intervention therapy,can stimulate blood flow to different degrees and have a positive effect on vascular endothelial function.Through reviewing the occurrence of vascular endothelial dysfunction,as well as the dose-effect relationship and correlating molecular mechanisms between exercise adaption of vascular endothelial function and wall shear stress,the research discovers the unique characteristics of wall shear stress in improving vascular endothelial dysfunction through different methods,times and intensities of exercise.

关 键 词：血流剪切力 血管内皮功能障碍 运动 

分 类 号：G804.7[文化科学—运动人体科学]