原儿茶醛的神经保护作用机制研究进展  

Research progress on neuroprotective mechanism of protocatechuic aldehyde

作　　者：杨世瑜 肖雨 安春娜 邱昌龙 李继安 储金秀 YANG Shiyu;XIAO Yu;AN Chunna;QIU Changlong;LI Ji’an;CHU Jinxiu(Hebei Key Laboratory for Chronic Diseases,School of Basic Medical Sciences,North China University of Science and Technology,Tangshan 063210,China;Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Diabetes Mellitus and Its Complications,School of Traditional Chinese Medicine,North China University of Science and Technology,Tangshan 063210,China)

机构地区：[1]华北理工大学基础医学院,河北省慢性疾病基础医学重点实验室,河北唐山063210 [2]华北理工大学中医学院,河北省中西医结合防治糖尿病及其并发症重点实验室,河北唐山063210

出　　处：《中草药》2024年第7期2463-2471,共9页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81801522);河北省自然科学基金中医药联合基金重点项目(H2023209038);河北省高等学校科学技术研究项目(ZD2022141)。

摘　　要：原儿茶醛是一种存在于常用中药及一些草本植物中的酚酸类化合物,已被证明具有多种药理活性,如抗动脉粥样硬化、抗血栓形成、保护心肌细胞等。近年来的研究结果显示原儿茶醛对多种神经系统疾病具有改善作用,表明其在神经病变方面具有潜在的开发应用前景。结合国内外最新报道,综述了近25年原儿茶醛的神经保护作用及其机制的研究进展,为原儿茶醛用于神经系统疾病的进一步研究提供依据和思路。Protocatechuic aldehyde is a phenolic acid compound existing in common traditional Chinese medicine and some herbs.It has been proved to have a variety of pharmacological activities,such as anti-atherosclerosis,anti-thrombosis,and protection of myocardial cells.Recent research results showed that protocatechuic aldehyde could improve a variety of nervous system diseases,indicating that it has potential development and application prospects in neuropathy.Based on the latest reports at home and abroad,this paper reviews the research progress on the neuroprotective effect and mechanism of protocatechuic aldehyde in the past 25 years,providing the basis and ideas for further research on the application of protocatechuic aldehyde in nervous system diseases.

关 键 词：原儿茶醛 神经保护 抗动脉粥样硬化 抗血栓形成 保护心肌细胞 药动学 帕金森病 阿尔茨海默病 缺血性脑卒中 

分 类 号：R285[医药卫生—中药学]