秦艽化学成分及药理活性研究进展  

Research progress on chemical composition and pharmacological activity of Gentianae Macrophyllae Radix

作　　者：梁国成 段文贵[1] 陈舒茵[2] LIANG Guocheng;DUAN Wengui;CHEN Shuyin(School of Chemistry and Chemical Engineering,Guangxi University,Nanning 530004,China;Drug Research and Development Center,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530011,China)

机构地区：[1]广西大学化学化工学院,广西南宁530004 [2]广西中医药大学附属瑞康医院,药物研发中心,广西南宁530011

出　　处：《中草药》2024年第7期2472-2490,共19页Chinese Traditional and Herbal Drugs

基　　金：广西中医药管理局中医药适宜技术开发与推广项目(GZSY22-44);广西高校中青年教师科研基础能力提升项目(2021KY0322,2021KY0286,2017KY0290)。

摘　　要：秦艽Gentianae Macrophyllae Radix是我国重要的常用传统中药品种之一,其资源丰富,成分多样,作用广泛,具有极大的药用价值。目前发现秦艽药材中化学成分主要有环烯醚萜类、三萜、木脂素、黄酮、生物碱、甾体、多糖等类型成分,药理作用主要有抗炎、镇痛、抗菌、抗病毒、抗肿瘤、免疫调节、保护肝脏、抗氧化等药理活性。通过检索近20年国内外相关文献,对秦艽的成分和药理活性进行综述,旨在探究对秦艽成分和药理的客观认识,为其临床合理用药和质量评价等提供参考。Qinjiao(Gentianae Macrophyllae Radix)is one of the important commonly used traditional Chinese medicine varieties in China.It is rich in resources,diverse in ingredients,has a wide range of functions with great medicinal value.At present,it has been found that the chemical components in Gentianae Macrophyllae Radix medicinal herbs mainly include iridoids,triterpenes,lignans,flavonoids,alkaloids,steroids,polysaccharides and other ingredients.The pharmacological effects are mainly anti-inflammatory,analgesic,antibacterial,antiviral,anti-tumor,immune regulation,liver protection,antioxidant and other pharmacological activities.By retrieving relevant domestic and foreign literature databases in the past 20 years,the chemical constituents and pharmacological activities of Gentianae Macrophyllae Radix were reviewed,aiming to explore the objective understanding of the medicinal components and pharmacological effects of Gentianae Macrophyllae Radix,and provide reference for the rational drug use in clinic and quality evaluation of Gentianae Macrophyllae Radix.

关 键 词：秦艽 抗炎 抗病毒 抗肿瘤 马钱苷 山栀苷 龙胆苦苷 熊果酸 刺槐黄素 β-香树脂醇 

分 类 号：R284[医药卫生—中药学]